, Volume 13, Issue 4, pp 323-327
Date: 28 Feb 2006

Properties of a Calcium Phosphate Cement Synergistically Reinforced by Chitosan Fiber and Gelatin

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Calcium phosphate cement (CPC) composite by the incorporation of chitosan fiber (CF) and gelatin was investigated for flexural strength, phase composition, microstructure, and in vitro cellular response. The results demonstrated that the incorporation improved the flexural strength significantly (maximum, 12.31 MPa), together with accelerating the conversion of CPC components to hydroxyapatite (HA). Rat bone marrow stromal cells (RBMSCs) spread and grew actively on the composite discs. Short-term minimum essential medium (MEM) extraction tests showed no cell growth inhibition. These results indicated that the new composite not only had a reinforced flexural property, but it was also beneficial for RBMSC growth.