The Journal of Primary Prevention

, Volume 33, Issue 4, pp 209–222

Design of a Randomized Controlled Trial of a Web-Based Intervention to Reduce Cardiovascular Disease Risk Factors Among Remote Reservation–Dwelling American Indian Adults with Type 2 Diabetes

  • Jeffrey A. Henderson
  • Jessica Chubak
  • Joan O’Connell
  • Maria C. Ramos
  • Julie Jensen
  • Jared B. Jobe
  • On Behalf of the LOWPK Project Team
Research Methods and Practice

DOI: 10.1007/s10935-012-0276-x

Cite this article as:
Henderson, J.A., Chubak, J., O’Connell, J. et al. J Primary Prevent (2012) 33: 209. doi:10.1007/s10935-012-0276-x

Abstract

We describe a randomized controlled trial, the Lakota Oyate Wicozani Pi Kte (LOWPK) trial, which was designed to determine whether a Web-based diabetes and nutritional intervention can improve risk factors related to cardiovascular disease (CVD) among a group of remote reservation–dwelling adult American Indian men and women with type 2 diabetes who are at high risk for CVD. Enrollment on a rolling basis of 180 planned participants began during 2009; an average 18-month follow-up was completed by June 2011. The primary outcome variable is change in glycosylated hemoglobin level after an average 18-month follow-up period. Secondary outcome variables include changes in low-density lipoprotein cholesterol, systolic blood pressure, body mass index, and smoking status, as well as an evaluation of intervention cost-effectiveness. If effective, the LOWPK trial may serve as a guide for future chronic disease intervention trials in remote, technologically challenged settings.

Keywords

American IndiansCardiovascular diseaseRisk reductionInterventionWeb-based

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Jeffrey A. Henderson
    • 1
  • Jessica Chubak
    • 4
  • Joan O’Connell
    • 5
  • Maria C. Ramos
    • 1
  • Julie Jensen
    • 1
  • Jared B. Jobe
    • 2
    • 3
  • On Behalf of the LOWPK Project Team
  1. 1.Black Hills Center for American Indian HealthRapid CityUSA
  2. 2.Division of Cardiovascular SciencesNational Heart, Lung, and Blood InstituteBethesdaUSA
  3. 3.Division of Cancer Control and Population SciencesNational Cancer InstituteRockvilleUSA
  4. 4.Group Health Research InstituteSeattleUSA
  5. 5.Department of Community and Behavioral HealthColorado School of Public Health, University of Colorado DenverAuroraUSA