Article

The Protein Journal

, Volume 29, Issue 6, pp 387-393

First online:

Towards the Development of Hemerythrin-Based Blood Substitutes

  • Augustin C. MotAffiliated withDepartment of Chemistry and Chemical Engineering, “Babes-Bolyai” University
  • , Alina RomanAffiliated withDepartment of Chemistry and Chemical Engineering, “Babes-Bolyai” University
  • , Iulia LupanAffiliated withDepartment of Biology, “Babes-Bolyai” University
  • , Donald M. KurtzJrAffiliated withDepartment of Chemistry, University of Texas at San Antonio
  • , Radu Silaghi-DumitrescuAffiliated withDepartment of Chemistry and Chemical Engineering, “Babes-Bolyai” University Email author 

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Abstract

Hemerythrin is proposed as an alternative to hemoglobin-based blood substitutes. In contrast to hemoglobin, hemerythrin exhibits negligible reactivity towards oxidative and nitrosative stress agents (peroxide, nitric oxide, nitrite). Protocols for attachment of polyethylene glycol and glutaraldehyde cross-linking of Hr are described. These derivatizations appear to have favorable effects on O2 affinity and autoxidation rates for use in blood substitutes. Based on lessons learned from hemoglobin-based blood substitutes, these derivatizations should also help limit extravasation and antigenicity of a hemerythrin-based blood substitute.

Keywords

Hemerythrin Blood substitute Oxygen carrier Hemoglobin