The Protein Journal

, Volume 27, Issue 6, pp 371-375

Isolation and Characterization of Low-Molecular-Weight Chromium-binding Substance (LMWCr) from Chicken Liver

  • Margarita VieraAffiliated withDepartment of Chemistry, Georgia Southern University
  • , C. Michele Davis-McGibonyAffiliated withDepartment of Chemistry, Georgia Southern University Email author 

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Chromodulin (also known as low-molecular-weight chromium-binding substance, LMWCr) is a chromium-binding oligopeptide proposed to play a role in insulin signaling and chromium transport in mammals. This laboratory has isolated and purified this material from a non-mammalian source, an avian. Spectroscopic and physical characterization of the isolated material suggests the material is an oligopeptide with a multinuclear chromium assembly bridged via asparatate and glutamate residues very similar to its mammalian counterparts. The isolated material also possesses a biological activity similar to other LMWCr isolates.


Chromium Chicken Low-molecular-weight chromium-binding substance Chromodulin