, Volume 18, Issue 3-4, pp 253-255
Date: 05 Nov 2013

Obesity and Breast Cancer: A Multipartite Connection

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It is our great pleasure to provide a brief introduction to this special issue of the Journal of Mammary Gland Biology and Neoplasia that is devoted to obesity and breast cancer. This issue contains reviews discussing the impact of obesity on breast cancer and dissecting the underlying molecular networks that, in our opinion, represent key pathways mediating the effects of obese state on breast carcinogenesis. In the last few years, basic science has advanced to the point where innovative tools have been developed to study and target the key nodes of obesity-breast cancer link; these models and emerging therapeutic targets will be discussed.

This is a very timely issue. The prevalence of overweight and obesity has dramatically increased in the last two decades in the United States and many other countries. Notably, obesity is second only to tobacco as a leading risk factor for cancer and nearly 30 % of cancers are attributable to obesity. The association of obesity with breast cancer ha