Journal of Mammary Gland Biology and Neoplasia

, Volume 17, Issue 3, pp 217–228

Targeting Inhibitors of Apoptosis Proteins (IAPs) For New Breast Cancer Therapeutics

  • Shaomeng Wang
  • Longchuan Bai
  • Jianfeng Lu
  • Liu Liu
  • Chao-Yie Yang
  • Haiying Sun
Article

DOI: 10.1007/s10911-012-9265-1

Cite this article as:
Wang, S., Bai, L., Lu, J. et al. J Mammary Gland Biol Neoplasia (2012) 17: 217. doi:10.1007/s10911-012-9265-1

Abstract

Apoptosis resistance is a hallmark of human cancer. Research in the last two decades has identified key regulators of apoptosis, including inhibitor of apoptosis proteins (IAPs). These critical apoptosis regulators have been targeted for the development of new cancer therapeutics. In this article, we will discuss three members of IAP proteins, namely XIAP, cIAP1 and cIAP2, as cancer therapeutic targets and the progress made in developing new cancer therapeutic agents to target these IAP proteins.

Keywords

Apoptosis IAPs Smac Small-molecule drugs 

Abbreviations

AIF

Apoptosis-Inducing Factor

Apaf-1

Apoptotic protease activating factor 1

Apo2L

Apo2 ligand

Apo3L

Apo3 ligand

Bcl-2

B-cell lymphoma 2

BIR

Baculoviral IAP Repeat domain

CARD

Caspase Recruitment Domain

CD95

Cluster of Differentiation 95

cFLIP

cellular FLICE-inhibitory protein

cIAP1

cellular Inhibitor of Apoptosis Protein 1

cIAP2

cellular Inhibitor of Apoptosis Proteins 2

dATP

Deoxyadenosine triphosphate

DIABLO

Direct IAP-Binding protein with Low PI

DISC

Death-Inducing Signaling Complex

DR

Death Receptor

FADD

Fas-Associated protein with Death Domain

FasR

Fas Receptor

IAPs

Inhibitors of Apoptosis Proteins

IHC

Immunohistochemistry

LRIG1

Leucine-Rich repeats and immunoglobulin-like domains protein 1

ML-IAP

Melanoma Inhibitor of Apoptosis Protein

NCI

National Cancer Institute

NFκB

Nuclear Factor kappa-light-chain-enhancer of activated B cells

PMBC

Peripheral Mononuclear Blood cells

RING

Really Interesting New Gene

RIPK1

Receptor-Interacting serine/threonine-protein Kinase 1

RTK

Receptor Tyrosine Kinase

Smac

Second Mitochondria-derived Activator of Caspases

TNF

Tumor Necrosis Factor

TNF-alpha

Tumor Necrosis Factor-alpha

TNFR

Tumor Necrosis Factor Receptor

TRADD

TNFR Associated DEATH Domain

TRAF

TNF Receptor Associated Factor

TRAIL

TNF Related Apoptosis-Inducing Ligand

UBA

Ubiquitin-Associated domain

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Shaomeng Wang
    • 1
  • Longchuan Bai
    • 1
  • Jianfeng Lu
    • 1
  • Liu Liu
    • 1
  • Chao-Yie Yang
    • 1
  • Haiying Sun
    • 1
  1. 1.Comprehensive Cancer Center and Departments of Internal Medicine, Pharmacology and Medicinal ChemistryUniversity of MichiganAnn ArborUSA

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