Journal of Mammary Gland Biology and Neoplasia

, Volume 16, Issue 4, pp 421–432

Gene Polymorphisms: The Keys for Marker Assisted Selection and Unraveling Core Regulatory Pathways for Mastitis Resistance

Authors

    • Department of Animal ScienceThe University of Tennessee
  • A. A. Elliott
    • Department of Veterinary PathobiologyUniversity of Missouri
Article

DOI: 10.1007/s10911-011-9238-9

Cite this article as:
Pighetti, G.M. & Elliott, A.A. J Mammary Gland Biol Neoplasia (2011) 16: 421. doi:10.1007/s10911-011-9238-9

Abstract

One of the most frequent mammary diseases impacting lactating animals is mastitis, an inflammation of the mammary gland most commonly caused by bacterial infection. The severity of mastitis is greatly influenced by the invading organism and the subsequent immune response which must recognize the foreign organism, recruit immune cells, eliminate the invading pathogen, and resolve the inflammatory response. The speed, strength, and duration of this response and subsequent disease susceptibility are critically tied to the genetic background of an animal. However, the genetic contribution has been difficult to identify due to the complex interactions that must occur for effective disease resistance. Recent studies have utilized polymorphisms to better define the genes and chromosomal regions that contribute to mastitis resistance. This review will examine these studies with primary emphasis in bovine systems, as the most work regarding mastitis has been conducted in this species.

Keywords

SNPQTLDairyMastitisImmunity

Abbreviations

SNP

single nucleotide polymorphism

QTL

quantitative trait loci

Copyright information

© Springer Science+Business Media, LLC 2011