Journal of Mammary Gland Biology and Neoplasia

, Volume 15, Issue 4, pp 381–387

Stromal Mediation of Radiation Carcinogenesis

Article

DOI: 10.1007/s10911-010-9197-6

Cite this article as:
Barcellos-Hoff, M.H. J Mammary Gland Biol Neoplasia (2010) 15: 381. doi:10.1007/s10911-010-9197-6

Abstract

Ionizing radiation is a well-established carcinogen in human breast and rodent mammary gland. This review addresses evidence that radiation elicits the critical stromal context for cancer, affecting not only frequency but the type of cancer. Recent data from the breast tumors of women treated with radiation therapy and the cellular mechanisms evident in experimental models suggest that radiation effects on stromal-epithelial interactions and tissue composition are a major determinant of cancer development.

Keywords

Ionizing radiationCarcinogenesisStromal-epithelial interactionsMammary gland

Abbreviations

TGFβ

Transforming growth factor β

ER

estrogen receptor

PR

progesterone receptor

EMT

epithelial-mesenchymal transition

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Departments of Radiation Oncology and Cell BiologyNew York University School of MedicineNew YorkUSA