Journal of Mammary Gland Biology and Neoplasia

, Volume 15, Issue 2, pp 213–223

microRNAs and EMT in Mammary Cells and Breast Cancer

  • Josephine A. Wright
  • Jennifer K. Richer
  • Gregory J. Goodall

DOI: 10.1007/s10911-010-9183-z

Cite this article as:
Wright, J.A., Richer, J.K. & Goodall, G.J. J Mammary Gland Biol Neoplasia (2010) 15: 213. doi:10.1007/s10911-010-9183-z


MicroRNAs are master regulators of gene expression in many biological and pathological processes, including mammary gland development and breast cancer. The differentiation program termed the epithelial to mesenchymal transition (EMT) involves changes in a number of microRNAs. Some of these microRNAs have been shown to control cellular plasticity through the suppression of EMT-inducers or to influence cellular phenotype through the suppression of genes involved in defining the epithelial and mesenchymal cell states. This has led to the suggestion that microRNAs maybe a novel therapeutic target for the treatment of breast cancer. In this review, we will discuss microRNAs that are involved in EMT in mammary cells and breast cancer.


microRNAepithelial to mesenchymal transitionmammary cellsbreast cancer





epithelial to mesenchymal transition


mesenchymal to epithelial transition


Transforming Growth Factor β


human mammary epithelial cell


breast cancer stem cell

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Josephine A. Wright
    • 1
  • Jennifer K. Richer
    • 2
  • Gregory J. Goodall
    • 1
    • 3
  1. 1.Centre for Cancer BiologySA PathologyAdelaideAustralia
  2. 2.Department of PathologyUniversity of ColoradoAuroraUSA
  3. 3.Department of MedicineUniversity of AdelaideAdelaideAustralia