Journal of Mammary Gland Biology and Neoplasia

, 13:279

The Relevance of Mouse Models to Understanding the Development and Progression of Human Breast Cancer

Article

DOI: 10.1007/s10911-008-9093-5

Cite this article as:
Allred, D.C. & Medina, D. J Mammary Gland Biol Neoplasia (2008) 13: 279. doi:10.1007/s10911-008-9093-5

Abstract

Mouse modeling of human breast cancer has developed tremendously over the past ten years. Human breast cancer is characterized by enormous biological diversity and, collectively, the new models have come much closer to encompassing this diversity. They have provided a deeper understanding of the fundamental events that mediate the initiation, development, and progression of breast cancer, and they offer new opportunities to develop and test strategies to treat and, perhaps, even prevent the disease. This chapter reviews the historical development of mouse models of breast cancer and highlights some of their major strengths, weaknesses, and contributions.

Keywords

Breast cancerMouse model

Abbreviations

TDLUs

terminal duct lobular units

CCH

columnar cell hyperplasia

HELUs

hyperplastic enlarged lobular units

ADH

atypical ductal hyperplasia

DCIS

ductal carcinoma in situ

IBC

invasive breast cancer

ALH

atypical lobular hyperplasia

LCIS

lobular carcinoma in situ

ILC

infiltrating lobular carcinoma

EMT

epithelial-mesenchymal transition

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Department of Pathology and ImmunologyWashington University School of MedicineSt. LouisUSA
  2. 2.Department of Cellular and Molecular BiologyBaylor College of MedicineHoustonUSA