Journal of Mammary Gland Biology and Neoplasia

, 12:153

Organotropism of Breast Cancer Metastasis

Article

DOI: 10.1007/s10911-007-9047-3

Cite this article as:
Lu, X. & Kang, Y. J Mammary Gland Biol Neoplasia (2007) 12: 153. doi:10.1007/s10911-007-9047-3

Abstract

Breast cancer causes mortality by metastasizing to a variety of vital organs, such as bone, lung, brain and liver. Effective therapeutic intervention of this deadly process relies on a better mechanistic understanding of metastasis organotropism. Recent studies have confirmed earlier speculations that metastasis is a non-random process and is dependent on intricate tumor-stroma interactions at the target organ. Both the intrinsic properties of breast cancer cells and the host organ microenvironment are important in determining the efficiency of organ-specific metastasis. Advances in animal modeling, in vivo imaging and functional genomics have accelerated the discovery of important molecular mediators of organ-specific metastasis. A conceptual framework of breast cancer organotropism is emerging and will be instrumental in guiding future efforts in this exciting research field.

Keywords

Breast cancerMetastasisOrganotropismTissue-specific metastasisBone metastasisLung metastasisCancer stem cellMetastasis niche

Abbreviations

ADAMTS1

a disintegrin and metalloproteinase with thrombospondin type 1 motif1

BBB

blood brain barrier

BMP

bone morphogenetic protein

BSP

bone sialoprotein

CATK

cathepsin K

CSC

cancer stem cell

CTGF

connective tissue growth factor

CXCR4

CXC motif chemokine receptor 4

ECM

extracellular matrix

FGF

fibroblast growth factor

GM-CSF

granulocyte macrophage colony stimulating factor

IGF

insulin-like growth factor

IL

interleukin

JNK

Jun N-terminal kinase

MEC

mammary epithelial cell

M-CSF

macrophage colony-stimulating factor

MMP

matrix metalloproteinase

NFκB

nuclear factor kappa B

OPG

osteoprotegerin

OPN

osteopontin

PDGF

platelet-derived growth factor

PlGF

placental growth factor

PMN

pre-metastasis niche

PTHrP

parathyroid hormone-related protein

RANK

receptor activator of NFκB

RANKL

receptor activator of NFκB ligand

SDF1

stromal derived factor 1

TGFβ

transforming growth factor beta

TNFα

tumor necrosis factor alpha

TRAP

tartrate-resistant acid phosphatase

VCAM

vascular cell adhesion molecule

VEGF

vascular endothelial growth factor

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  1. 1.Department of Molecular BiologyPrinceton UniversityPrincetonUSA
  2. 2.Department of Molecular BiologyPrinceton UniversityPrincetonUSA