Journal of Mammary Gland Biology and Neoplasia

, Volume 12, Issue 1, pp 71–82

Microenvironment of the Involuting Mammary Gland Mediates Mammary Cancer Progression

Authors

    • AMC Cancer Research CenterUniversity of Colorado Health Science Center
    • Department of Medicine, Division of Medical OncologyUniversity of Colorado Health Science Center
    • Department of Obstetrics and Gynecology, Division of Reproductive SciencesUniversity of Colorado Health Science Center
    • Department of Cell and Developmental BiologyUniversity of Colorado Health Science Center
  • Jenean O’Brien
    • Department of Medicine, Division of Medical OncologyUniversity of Colorado Health Science Center
  • Michael Rudolph
    • Department of Obstetrics and Gynecology, Division of Reproductive SciencesUniversity of Colorado Health Science Center
  • Torsten Stein
    • Division of Cancer Sciences and Molecular Pathology, Western InfirmaryUniversity of Glasgow
  • Virginia Borges
    • Department of Medicine, Division of Medical OncologyUniversity of Colorado Health Science Center
    • University of Colorado Cancer CenterUniversity of Colorado Health Science Center
Article

DOI: 10.1007/s10911-007-9039-3

Cite this article as:
Schedin, P., O’Brien, J., Rudolph, M. et al. J Mammary Gland Biol Neoplasia (2007) 12: 71. doi:10.1007/s10911-007-9039-3

Abstract

Breast cancer diagnosed after a completed pregnancy has higher metastatic potential and therefore a much poorer prognosis. We hypothesize that following pregnancy the process of mammary gland involution, which returns the gland to its pre-pregnant state, co-opts some of the programs of wound healing. The pro-inflammatory milieu that results, while physiologically normal, promotes tumor progression. In this review, the similarities between mammary gland involution after cessation of milk-production and pathological tissue remodeling are discussed in light of emerging data demonstrating a role for pathological tissue remodeling in cancer.

Keywords

Breast cancerCollagenFibronectinMatrix-turnoverMetastasis

Abbreviations

ECM

extracellular matrix

TGFβ

transforming growth factor beta

FN

fibronectin

LN1

laminin 1

LN5

laminin 5

MMP

matrix metalloproteinase

CTGF

connective tissue growth factor

SD

Sprague–Dawley

Copyright information

© Springer Science+Business Media, LLC 2007