Journal of Mammary Gland Biology and Neoplasia

, Volume 11, Issue 3, pp 229–238

Mammary Gland Macrophages: Pleiotropic Functions in Mammary Development

  • Kathryn L. Schwertfeger
  • Jeffrey M. Rosen
  • Donald A. Cohen
Article

DOI: 10.1007/s10911-006-9028-y

Cite this article as:
Schwertfeger, K.L., Rosen, J.M. & Cohen, D.A. J Mammary Gland Biol Neoplasia (2006) 11: 229. doi:10.1007/s10911-006-9028-y

Abstract

Mammary gland development is a complex process involving epithelial cells and supporting stromal cells. Macrophages (M∅s) are an important component of the mammary gland stroma and are critical for normal mammary gland development; however, the mechanisms by which macrophages regulate these processes are not well understood. M∅s are known to interact with numerous cell types, including epithelial cells, fibroblasts, adipocytes, and endothelial cells, all of which are significant components of mammary gland development. Therefore, the purpose of this review is to describe the interactions between M∅s and these various cell types and use this knowledge to identify potential functions of M∅s in the mammary gland.

Keywords

Mammary glandMacrophageDevelopmentEpitheliumStroma

Abbreviations

M∅

macrophage

TEB

terminal end bud

TAM

tumor associated macrophage

ECM

extracellular matrix

LPS

lipopolysaccharide

IFN

interferon

IL

interleukin

TGF

transforming growth factor

CSF-1

colony stimulating factor-1

CSF-1R

colony stimulating factor-1 receptor

DT

diphtheria toxin

MMTV

mouse mammary tumor virus

EGF

epidermal growth factor

PyMT

polyoma middle T

FGF

fibroblast growth factor

WAT

white adipose tissue

TNF

tumor necrosis factor

VEGF

vascular endothelial growth factor

TP

thymidine phosphorylase

PGE2

prostaglandin E2

PDGF

platelet derived growth factor

MMP

matrix metalloproteinase

IGF

insulin-like growth factor

Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  • Kathryn L. Schwertfeger
    • 1
  • Jeffrey M. Rosen
    • 2
  • Donald A. Cohen
    • 3
  1. 1.Department of Lab Medicine and PathologyUniversity of Minnesota Cancer CenterMinneapolisUSA
  2. 2.Department of Molecular and Cellular BiologyBaylor College of MedicineHoustonUSA
  3. 3.Department of Microbiology, Immunology and Molecular GeneticsUniversity of KentuckyLexingtonUSA