, Volume 11, Issue 1, pp 27-39

Inhibitors of Insulin-like Growth Factor Signaling: A Therapeutic Approach for Breast Cancer

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Abstract

The peptide growth factors IGF-I and IGF-II not only play a role in the development of the mammary gland but are also implicated in breast cancer. Several reagents disrupting IGF signaling have been developed and clinical trials validating IGF signaling as a target in cancer therapy are underway. This review highlights the approaches to inhibiting IGF signaling in breast cancer.