Journal of Mammary Gland Biology and Neoplasia

, Volume 10, Issue 2, pp 119–128

Calcium Secretion into Milk

Authors

  • Margaret C. Neville
    • University of Colorado Health Sciences Center at Fitzsimmons
    • UCHSC at Fitzsimmons, Reproductive Sciences
    • UCHSC at Fitzsimmons, Reproductive Sciences
Article

DOI: 10.1007/s10911-005-5395-z

Cite this article as:
Neville, M.C. J Mammary Gland Biol Neoplasia (2005) 10: 119. doi:10.1007/s10911-005-5395-z

Abstract

Ionized calcium ([Ca2+]) is present in milk at concentrations around 3 mM, a concentration that drives the formation of complexes with citrate, phosphate, and casein, thereby generating compounds that carry the major portion of calcium in milk. In humans and cows, where it has been studied, changes in milk calcium appear to be regulated by the amount of citrate and casein in milk rather than changes in [Ca2+]. Most or all of the calcium in milk is likely derived through exocytosis of secretory vesicles derived from the Golgi compartment where a calcium ATPase mediates transport from the cytoplasm. The identity of the transporters is not yet certain but gene expression for the plasma membrane calcium ATPase, PMCA2bw, and the secretory pathway calcium ATPase, SPCA, is highly upregulated during lactation. Currently nothing appears to be known about the mechanisms that mediate transport of calcium across the basolateral membrane of the alveolar cell.

Keywords

milkcalciumsecretioncalcium ATPasescasein micelle

Abbreviations:

[Ca2+]

concentration of ionized calcium

ER

endoplasmic reticulum

PMCA

plasma membrane calcium transporter

PMR1

yeast calcium ATPase

SERCA

sarcoplasmic reticulum/ER calcium ATPase

SPCA

secretory pathway calcium ATPase

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Copyright information

© Springer Science + Business Media, Inc. 2005