Journal of Mammary Gland Biology and Neoplasia

, Volume 10, Issue 1, pp 87–100

Dietary Factors Modifying Breast Cancer Risk and Relation to Time of Intake

  • Airo Tsubura
  • Norihisa Uehara
  • Yasuhiko Kiyozuka
  • Nobuaki Shikata
Article

DOI: 10.1007/s10911-005-2543-4

Cite this article as:
Tsubura, A., Uehara, N., Kiyozuka, Y. et al. J Mammary Gland Biol Neoplasia (2005) 10: 87. doi:10.1007/s10911-005-2543-4
  • 120 Downloads

Abstract

Multiple factors contribute to the development of human breast cancer. However, environmental factors, especially dietary factors, appear to have the greatest effects. Evidence obtained in epidemiological studies has been corroborated by laboratory findings. Dietary components strongly associated with breast cancer include fat and phytochemicals. A diet high in n-3 polyunsaturated fatty acid (PUFA) or monounsaturated fatty acid (MUFA) and low in n-6 PUFA is protective against breast cancer. Some phytochemicals present in fruits and vegetables are also protective. Time of intake appears to be important: lifetime protection may be achieved if one is exposed to a dietary factor that lowers breast cancer risk early in life. Synergistic and antisynergistic interactions between dietary factors can modify breast cancer risk. The available evidence suggests that breast cancer risk can be reduced by early dietary intervention.

breast cancer mammary cancer diet nutrition fat phytochemical phytoestrogen 

Abbreviations used

CDHA

conjugated docosahexaenoic acid

CLA

conjugated linoleic acid

DADS

diallyl disulfide

DHA

docosahexaenoic acid

DMBA

7,12-dimethylbenz(α) anthracene

EGFR

epidermal growth factor receptor

EPA

eicosapentaenoic acid

ER

estrogen receptor

LA

linoleic acid

MNU

N-methyl-N-nitrosourea

MUFA

monounsaturated fatty acid

OA

oleic acid

PCNA

proliferating cell nuclear antigen

PgR

progesterone receptor

PhIP

2-amino-1-methyl- 6-phenylimidazo [4-5-b] pyridine

POH

perillyl alcohol

PUFA

polyunsaturated fatty acid

SDG

secoisolariciresinol diglycoside

SFA

saturated fatty acid

TEB

terminal end bud

TGF

transforming growth factor

Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • Airo Tsubura
    • 1
    • 2
  • Norihisa Uehara
    • 1
  • Yasuhiko Kiyozuka
    • 1
  • Nobuaki Shikata
    • 1
  1. 1.Department of Pathology IIKansai Medical UniversityOsakaJapan
  2. 2.Department of Pathology IIKansai Medical UniversityOsakaJapan

Personalised recommendations