Journal of Mammary Gland Biology and Neoplasia

, Volume 9, Issue 4, pp 393–404

Viscoelastic Imaging of Breast Tumor Microenvironment With Ultrasound

  • Michael F. Insana
  • Claire Pellot-Barakat
  • Mallika Sridhar
  • Karen K. Lindfors
Article

DOI: 10.1007/s10911-004-1409-5

Cite this article as:
Insana, M.F., Pellot-Barakat, C., Sridhar, M. et al. J Mammary Gland Biol Neoplasia (2004) 9: 393. doi:10.1007/s10911-004-1409-5

Abstract

Imaging systems are most effective for detection and classification when they exploit contrast mechanisms specific to particular disease processes. A common example is mammography, where the contrast depends on local changes in cell density and the presence of microcalcifications. Unfortunately the specificity for classifying malignant breast disease is relatively low for many current diagnostic techniques. This paper describes a new ultrasonic technique for imaging the viscoelastic properties of breast tissue. The mechanical properties of glandular breast tissue, like most biopolymers, react to mechanical stimuli in a manner specific to the microenvironment of the tissue. Elastic properties allow noninvasive imaging of desmoplasia while viscous properties describe metabolism-dependent features such as pH. These ultrasonic methods are providing new tools for studying disease mechanisms as well as improving diagnosis.

Keywords

breast cancer desmoplasia molecular signaling strain imaging stromal reaction pH imaging tumor metabolism ultrasound 

Copyright information

© Springer Science + Business Media, Inc. 2004

Authors and Affiliations

  • Michael F. Insana
    • 1
    • 3
  • Claire Pellot-Barakat
    • 1
  • Mallika Sridhar
    • 1
  • Karen K. Lindfors
    • 2
  1. 1.Department of Biomedical EngineeringUniversity of CaliforniaDavis
  2. 2.Department of RadiologyUniversity of California–Davis Medical CenterSacramento
  3. 3.Department of Biomedical EngineeringUniversity of CaliforniaDavis

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