Journal of Inorganic and Organometallic Polymers and Materials

, Volume 16, Issue 3, pp 249–257

Synthesis of Organotin Polyamine Ethers Containing Acyclovir and their Preliminary Anticancer and Antiviral Activity

Authors

    • Department of Chemistry and BiochemistryFlorida Atlantic University
    • Florida Center for Environmental Studies
  • Theodore S. Sabir
    • Department of Chemistry and BiochemistryFlorida Atlantic University
    • Department of ChemistryProvidence Christian College
  • Michael R. Roner
    • Department of BiologyUniversity of Texas at Arlington
  • Kimberely Shahi
    • Department of BiologyUniversity of Texas at Arlington
  • Robert E. Bleicher
    • California State University Channel Islands
  • Joanne L. Roehr
    • Department of BiologyUniversity of Texas at Arlington
  • Kelly D. Bassett
    • Department of BiologyUniversity of Texas at Arlington
Article

DOI: 10.1007/s10904-006-9050-y

Cite this article as:
Carraher, C.E., Sabir, T.S., Roner, M.R. et al. J Inorg Organomet Polym (2006) 16: 249. doi:10.1007/s10904-006-9050-y

Abstract

Organotin polyamine ethers containing acyclovir in their backbone were synthesized in moderate to high yield employing the aqueous interfacial polycondensation system. The products are high molecular weight polymers. Infrared spectroscopy of the products shows new bands characteristic of the formation of Sn–N and Sn–O bonds consistent with the proposed structure. MALDI-TOF MS below 2000 Da shows the presence of organotin and acyclovir units containing these two moieties. The products show moderate inhibition of a number of cancer cell lines and exhibit the ability to inhibit a number of viruses, particularly the herpes simplex virus-1 and varicella zoster virus that are responsible for herpes, chicken pox and shingles.

Keywords

Organotin polymers acyclovir interfacial polymerization MALDI-TOF MS herpes chicken pox small pox shingles reovirus ST3 HSV-1 viruses viruses bioterrorism VZV virus varicella zoster virus vaccinia WR virus herpes simplex virus anticancer drugs L929 cells 143 cells BS-C-1 cells vero cells

Copyright information

© Springer Science+Business Media, Inc. 2006