Journal of Gambling Studies

, Volume 31, Issue 1, pp 295–297

Pathological Gambling Induced by Dopamine Antagonists: A Case Report


  • Philipp Grötsch
    • Psychiatric Hospital of the University of Basel
    • Psychiatric Hospital of the University of Basel
  • Gerhard A. Wiesbeck
    • Psychiatric Hospital of the University of Basel
  • Undine Lang
    • Psychiatric Hospital of the University of Basel
Original Paper

DOI: 10.1007/s10899-013-9433-2

Cite this article as:
Grötsch, P., Lange, C., Wiesbeck, G.A. et al. J Gambl Stud (2015) 31: 295. doi:10.1007/s10899-013-9433-2


Pathological gambling is defined as inappropriate, persistent, and maladaptive gambling behaviour. It is a non-pharmacological addiction classified as an impulse control disorder. However, pathological gambling has been associated with dopamine agonist use. Here we report of a 28-year-old man with a first major depressive episode and a post-traumatic stress disorder who has been treated with a combination of the serotonine/noradrenaline reuptake inhibitor duloxetine and the tricyclic antidepressant maprotiline. The administration of antipsychotic flupentixole (up to 7 mg) turned this slight online poker gambler into an excessive gambler. Only after the discontinuation of the antidopaminergic agents and the switch to bupropion did this gambling behaviour stop which suggests a causal relationship between dopamine antagonists and pathological gambling.


Antipsychotic agentsGambling behaviourDopamine antagonists

Copyright information

© Springer Science+Business Media New York 2013