‘Battling my Biology’: Psychological Effects of Genetic Testing for Risk of Weight Gain
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The availability of genetic tests for multifactorial conditions such as obesity raises concerns that higher-risk results could lead to fatalistic reactions or lower-risk results to complacency. No study has investigated the effects of genetic test feedback for the risk of obesity in non-clinical samples. The present study explored psychological and behavioral reactions to genetic test feedback for a weight related gene (FTO) in a volunteer sample (n = 18) using semi-structured interviews. Respondents perceived the gene test result as scientifically objective; removing some of the emotion attached to the issue of weight control. Those who were struggling with weight control reported relief of self-blame. There was no evidence for either complacency or fatalism; all respondents emphasized the importance of lifestyle choices in long-term weight management, although they recognized the role of both genes and environment. Regardless of the test result, respondents evaluated the testing positively and found it motivating and informative. Genetic test feedback for risk of weight gain may offer psychological benefits beyond its objectively limited clinical utility. As the role of genetic counselors is likely to expand, awareness of reasons for genetic testing for common, complex conditions and reactions to the test result is important.
- Bennett, L., Thirlaway, K., & Murray, A. J. (2008). The stigmatising implications of presenting schizophrenia as a genetic disease. Journal of Genetic Counseling, 17, 550–559.
- Brownell, K. D., Kersh, R., Ludwig, D. S., Post, R. C., Puhl, R. M., Schwartz, M. B., et al. (2010). Personal responsibility and obesity: a constructive approach to a controversial issue. Health Affairs, 29(3), 379–387. CrossRef
- Campbell, M., Fitzpatrick, R., Haines, A., Kinmonth, A. L., Sandercock, P., Spiegelhalter, D., et al. (2000). Framework for design and evaluation of complex interventions to improve health. British Medical Journal, 321, 694–696. CrossRef
- Collins, F. (2010). Has the revolution arrived? Nature, 464, 674–675. CrossRef
- Condit, C. M., Gronnvoll, M., Landau, J., Shen, L., Wright, L., & Harris, T. M. (2009). Believing in both genetic determinism and behavioral action: a materialist framework and implications. Public Understanding of Science, 18, 730–746. CrossRef
- Conradt, M., Dierk, J. M., Schlumberger, P., Albohn, C., Rauh, E., Hinney, A., et al. (2009). A consultation with genetic information about obesity decreases self-blame about eating and leads to realistic weight loss goals in obese individuals. Journal of Psychosomatic Research, 66, 287–295. CrossRef
- Frayling, T. M., Timpson, N. J., Weedon, M. N., Zeggini, E., Freathy, R. M., Lindgren, C. M., et al. (2007). A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science, 316, 889–894. CrossRef
- Frosch, D. L., Mello, P., & Lerman, C. (2005). Behavioral consequences of testing for obesity risk. Cancer Epidemiology, Biomarkers & Prevention, 14, 1485–1489. CrossRef
- Grosse, S. D., McBride, C. M., Evans, J. P., & Khoury, M. J. (2009). Personal utility and genomic information: look before you leap. Genetics in Medicine, 11, 575–576. CrossRef
- Guh, D., Zhang, W., Bansback, N., Amarsi, Z., Birmingham, C. L., & Anis, A. (2009). The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis. BMC Public Health, 9(1), 88. CrossRef
- Harris, A., Kelly, S. E., & Wyatt, S. (2012). Counseling customers: emerging roles for genetic counselors in the direct-to-consumer genetic testing market. Journal of Genetic Counseling. doi:10.1007/s10897-012-9548-0.
- Harvey-Berino, J., Gold, E. C., West, D. S., Shuldiner, A. R., Walston, J., Starling, R. D., et al. (2001). Does genetic testing for obesity influence confidence in the ability to lose weight? A pilot investigation. Journal of the American Dietetic Association, 101, 1351–1353. CrossRef
- Leventhal, H. B., et al. (1997). Illness representations: theoretical foundations. In K. H. Petrie & J. A. Weinman (Eds.), Perception of health and illness (pp. 19–46). Amsterdam: Harwood Academic Publishers.
- Lippa, N. C., & Sanderson, S. C. (2012). Impact of information about obesity genomics on the stigmatization of overweight individuals: an experimental study. Obesity.
- Lock, M. (2006). When it runs in the family: putting susceptibility genes in perspective. Public Understanding of Science, 15, 277. CrossRef
- Loos, R. J., & Bouchard, C. (2003). Obesity–is it a genetic disorder? Journal of Internal Medicine, 254, 401–425. CrossRef
- Marteau, T. M., French, D. P., Griffin, S. J., Prevost, A. T., Sutton, S., Watkinson, C., et al. (2010). Effects of communicating DNA-based disease risk estimates on risk-reducing behaviours. Cochrane Database of Systematic Reviews, 10.
- Meisel, S. F., Walker, C., & Wardle, J. (2012). Psychological responses to genetic testing for weight gain: a vignette study. Obesity, 20(3), 540–546. CrossRef
- O’Brien, K. S. (2010). Reducing anti-fat prejudice in preservice health students: a randomized trial. Obesity, 18, 2138. CrossRef
- O’Rahilly, S., & Farooqi, I. S. (2008). Human obesity as a heritable disorder of the central control of energy balance. International Journal of Obesity (London), 32(Suppl 7), S55–S61. CrossRef
- Persky, S., Kaphingst, K. A., Condit, C. M., & McBride, C. M. (2007). Assessing hypothetical scenario methodology in genetic susceptibility testing analog studies: a quantitative review. Genetics in Medicine, 9, 727–738. CrossRef
- Puhl, R. M., & Heuer, C. A. (2012). The stigma of obesity: a review and update. Obesity, 17(5), 941–964. CrossRef
- Ritchie, J. (2003). Qualitative research practice: a guide for social science students and researchers. London: Sage Publications.
- Rogers, R. W. (1975). A protection motivation theory of fear appeals and attitude Change. The Journal of Psychology, 91, 93. CrossRef
- Rosenstock, I. M. (1988). Adoption and maintenance of lifestyle modifications. American Journal of Preventive Medicine, 4, 349–352.
- Saguy, A. C. (2005). Weighing both sides: morality, mortality, and framing contests over obesity. Journal of Health Politics, Policy and Law, 30, 869. CrossRef
- Sanderson, S. C., & Wardle, J. (2005). Will genetic testing for complex diseases increase motivation to quit smoking? Anticipated reactions in a survey of smokers. Health Education & Behavior, 32, 640–653. CrossRef
- Senior, V., Marteau, T. M., & Peters, T. J. (1999). Will genetic testing for predisposition for disease result in fatalism? A qualitative study of parents responses to neonatal screening for familial hypercholesterolaemia. Social Science & Medicine, 48, 1857–1860. CrossRef
- Shostak, S., Zarhin, D., & Ottman, R. (2011). What’s at stake? Genetic information from the perspective of people with epilepsy and their family members. Social Science & Medicine, 73, 645–654.
- Steinbrook, R. (2006). Imposing personal responsibility for health. The New England Journal of Medicine, 355(8), 753–756. CrossRef
- Sturm, A. C., & Manickam, K. (2012). Direct-to-consumer personal genomic testing: a case study and practical recommendations for “genomic counseling”. Journal of Genetic Counseling, 1–11.
- Townend, L. (2009). The moralizing of obesity: a new name for an old sin? Critical Social Policy, 29, 171–190. CrossRef
- Wardle, J., Carnell, S., Haworth, C. M., Farooqi, I. S., O’Rahilly, S., & Plomin, R. (2008). Obesity associated genetic variation in FTO is associated with diminished satiety. Journal of Clinical Endocrinology and Metabolism, 93, 3640–3643. CrossRef
- ‘Battling my Biology’: Psychological Effects of Genetic Testing for Risk of Weight Gain
Journal of Genetic Counseling
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- Genetic risk
- Personalized medicine
- Psychological reactions
- Weight gain
- Genetic testing
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