Journal of Genetic Counseling

, Volume 22, Issue 5, pp 603–612

Family Communication of BRCA1/2 Results and Family Uptake of BRCA1/2 Testing in a Diverse Population of BRCA1/2 Carriers

  • Julia Fehniger
  • Feng Lin
  • Mary S. Beattie
  • Galen Joseph
  • Celia Kaplan
Original Research

DOI: 10.1007/s10897-013-9592-4

Cite this article as:
Fehniger, J., Lin, F., Beattie, M.S. et al. J Genet Counsel (2013) 22: 603. doi:10.1007/s10897-013-9592-4

Abstract

Previous studies examining communication of BRCA1/2 results with relatives and family uptake of BRCA1/2 testing have sampled from predominantly white, high SES cohorts ascertained solely from tertiary care centers. No studies have focused on family communication and testing among relatives of diverse BRCA1/2 carriers. We conducted structured interviews with 73 BRCA1/2 carriers identified at a public hospital and a tertiary cancer center. We asked participants if each first- and second-degree relative was aware of their BRCA1/2 results and whether or not each relative had tested. Generalized estimating equations identified rates and predictors of family communication and testing. Participants disclosed their test results to 73 % of 606 eligible relatives and 31 % of 514 eligible relatives tested. Communication and testing rates were similar for relatives of participants from the public hospital and the tertiary cancer center. Hospital site was not a significant predictor of either result disclosure or relative uptake of testing. African American and Asian/Pacific Islander participants were significantly less likely to disclose their results to their relatives; relatives of African American participants were significantly less likely to test. Addressing these disparities will require further research into the best ways to facilitate family communication and counsel at-risk relatives of racially and socioeconomically diverse BRCA1/2 mutation carriers.

Keywords

BRCA1 BRCA2 Hereditary breast and ovarian cancer Family communication Family testing Disparities 

Copyright information

© National Society of Genetic Counselors, Inc. 2013

Authors and Affiliations

  • Julia Fehniger
    • 1
    • 2
  • Feng Lin
    • 3
  • Mary S. Beattie
    • 1
    • 3
  • Galen Joseph
    • 4
  • Celia Kaplan
    • 5
    • 6
  1. 1.Cancer Risk ProgramUniversity of California, San FranciscoSan FranciscoUSA
  2. 2.University of Michigan Medical SchoolAnn ArborUSA
  3. 3.Department of Epidemiology and BiostatisticsUniversity of California, San FranciscoSan FranciscoUSA
  4. 4.Department of Anthropology, History, and Social MedicineUniversity of California, San FranciscoSan FranciscoUSA
  5. 5.Department of MedicineUniversity of California, San FranciscoSan FranciscoUSA
  6. 6.University of California, San FranciscoSan FranciscoUSA

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