Journal of Genetic Counseling

, 18:130

Perceptions of Familial Risk in those Seeking a Genetic Risk Assessment for Alzheimer’s Disease

  • Susan Hiraki
  • Clara A. Chen
  • J. Scott Roberts
  • L. Adrienne Cupples
  • Robert C. Green
Original Research

DOI: 10.1007/s10897-008-9194-8

Cite this article as:
Hiraki, S., Chen, C.A., Roberts, J.S. et al. J Genet Counsel (2009) 18: 130. doi:10.1007/s10897-008-9194-8

Abstract

Perceived risk is a complex concept that influences the genetic counseling process and can affect client coping and behavior. Although the association between family history and risk perception is well recognized in the literature, no studies have explored this relationship specifically in those seeking genetic susceptibility testing for a common chronic condition. REVEAL is a randomized trial assessing the impact of APOE disclosure and genetic risk assessment for Alzheimer’s disease (AD). Using baseline REVEAL data, we hypothesized that there would be a significant association between the degree of AD family history and risk perception of AD, and that this relationship would be stronger in those who believed that genetics is a very important AD risk factor. In our sample of 293 participants, we found that a higher self-perceived risk of AD was associated with strength of family history of AD (p < 0.001), belief in genetics as an important AD risk factor (p < 0.001), being female (p < 0.001) and being Caucasian (p = 0.02). These results are the first to demonstrate the association between family history and risk perception in persons volunteering for genetic susceptibility testing for a common complex disease.

Keywords

Risk perceptionAlzheimer’s diseaseAPOEGenetic susceptibility testingRisk assessment

Copyright information

© National Society of Genetic Counselors, Inc. 2008

Authors and Affiliations

  • Susan Hiraki
    • 1
  • Clara A. Chen
    • 4
  • J. Scott Roberts
    • 6
  • L. Adrienne Cupples
    • 3
    • 5
  • Robert C. Green
    • 1
    • 2
    • 3
  1. 1.Dept. of NeurologyBoston University School of MedicineBostonUSA
  2. 2.Dept. of Medicine (Genetics)Boston University School of MedicineBostonUSA
  3. 3.Department of EpidemiologyBoston University School of Public HealthBostonUSA
  4. 4.Data Coordinating CenterBoston University School of Public HealthBostonUSA
  5. 5.Department of BiostatisticsBoston University School of Public HealthBostonUSA
  6. 6.Department of Health Behavior and Health EducationUniversity of Michigan School of Public HealthAnn ArborUSA