Participation of Interferon-Alpha in Regulation of Apoptosis
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- Bazhanova, E.D. J Evol Biochem Phys (2005) 41: 127. doi:10.1007/s10893-005-0045-z
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According to current data, endocrine system is closely related to immune system and interferons play an important role in this relationship. Interferons can inhibit cell proliferation or control apoptosis. Interferon-alpha (IA) produces a stimulatory effect on DNA sites controlling, via JAK/STAT-pathway, production of anti-apoptotic proteins of the Bcl-2 family. Besides, a very important property of IA is its ability to arrest the cell in the G1-G0 phase, which is what determines static effect of IA on growth of many tumors. Later, in these cells, either apoptosis can develop or they can survive. This depends on many factors including physiological state of the tissue and cell, its differentiation, stage of cellular cycle, etc.