Journal of Chemical Ecology

, Volume 34, Issue 9, pp 1253–1257

Individual Variation in 3-Methylbutanal: A Putative Link between Human Leukocyte Antigen and Skin Microflora

  • Sergey U. Savelev
  • Sanjay Antony-Babu
  • S. Craig Roberts
  • Huitu Wang
  • Anthony S. Clare
  • L. Morris Gosling
  • Marion Petrie
  • Michael Goodfellow
  • Anthony G. O’Donnell
  • Alan C. Ward
Article

DOI: 10.1007/s10886-008-9524-1

Cite this article as:
Savelev, S.U., Antony-Babu, S., Roberts, S.C. et al. J Chem Ecol (2008) 34: 1253. doi:10.1007/s10886-008-9524-1

Abstract

The human derma emits volatile compounds whose interaction with a receiver’s olfactory sensory system may affect individual recognition and mating preferences. Studies suggest that both genes and environmental factors determine characteristic odor of an individual. We used solid-phase microextraction and gas chromatography–mass spectrometry to identify 3-methylbutanal in human axillary odor; we showed that the abundance of this volatile compound varies significantly among individuals and demonstrated that its formation in vitro may be influenced by interaction between human leukocyte antigen peptide and dermal microflora.

Keywords

Human leukocyte antigen Human odor 3-Methylbutanal Skin microflora Solid-phase microextraction 

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Sergey U. Savelev
    • 1
    • 3
  • Sanjay Antony-Babu
    • 3
  • S. Craig Roberts
    • 4
  • Huitu Wang
    • 1
    • 2
  • Anthony S. Clare
    • 1
  • L. Morris Gosling
    • 2
  • Marion Petrie
    • 2
  • Michael Goodfellow
    • 3
  • Anthony G. O’Donnell
    • 3
  • Alan C. Ward
    • 3
  1. 1.School of Marine Science and TechnologyUniversity of NewcastleNewcastle upon TyneUK
  2. 2.Evolutionary Biology Group, School of Clinical Medical SciencesUniversity of NewcastleNewcastle upon TyneUK
  3. 3.School of Biology and PsychologyUniversity of NewcastleNewcastle upon TyneUK
  4. 4.School of Biological SciencesUniversity of LiverpoolLiverpoolUK

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