Journal of Clinical Psychology in Medical Settings

, Volume 14, Issue 4, pp 275–296

Non-pharmacologic Interventions for CFS: A Randomized Trial


    • Center for Community ResearchDePaul University
  • Susan Torres-Harding
    • Roosevelt University
  • Fred Friedberg
    • Stony Brook University
  • Katrina Corradi
    • Center for Community ResearchDePaul University
  • Mary Gloria Njoku
    • Center for Community ResearchDePaul University
  • Julie Donalek
    • Center for Community ResearchDePaul University
  • Nadia Reynolds
    • Center for Community ResearchDePaul University
  • Molly Brown
    • Center for Community ResearchDePaul University
  • Bing Bing Weitner
    • Northwestern University
  • Alfred Rademaker
    • Northwestern University
  • Morris Papernik
    • Rush University Medical Center

DOI: 10.1007/s10880-007-9090-7

Cite this article as:
Jason, L.A., Torres-Harding, S., Friedberg, F. et al. J Clin Psychol Med Settings (2007) 14: 275. doi:10.1007/s10880-007-9090-7


Non-pharmacological behavioral treatments for CFS have been suggested as promising. These trials have tested protocols composed of behavioral, cognitive and cognitive–behavioral interventions but there have been few efforts to differentially evaluate their outcomes. The primary purpose of the current study was to evaluate the effectiveness of nurse delivered non-pharmacologic interventions. In the present study, 114 participants diagnosed with CFS were randomly assigned to four 6-month interventions. The interventions were: cognitive–behavior therapy, cognitive therapy, anaerobic activity, and a relaxation control group. The study found that these interventions led to increases in several areas of functioning, with more consistent changes occurring among those participants in the cognitive condition. For the 25 variables in this study, significant change occurred for 28%, 20%, 16%, and 12% of the variables for the cognitive, cognitive behavior therapy, anaerobic activity, and relaxation conditions, respectively. However, the majority of participants continued to be diagnosed with CFS following the treatment trial. Implications of these findings are discussed.


CFSMENon-pharmacologicTreatmentTrialCognitive–behavior therapy

Copyright information

© Springer Science+Business Media, LLC 2007