Journal of Contemporary Psychotherapy

, Volume 39, Issue 2, pp 93–100

Just How Effective are Antidepressant Medications? Results of a Major New Study

  • John J. Boren
  • Allan M. Leventhal
  • H. Edmund Pigott
Original Paper

DOI: 10.1007/s10879-008-9095-z

Cite this article as:
Boren, J.J., Leventhal, A.M. & Edmund Pigott, H. J Contemp Psychother (2009) 39: 93. doi:10.1007/s10879-008-9095-z


The STAR*D (Sequenced Treatment Alternatives to Relieve Depression) project was the largest and most extensive trial of antidepressants ever conducted. The study used state of- the-art methods to treat real patients coming to a hospital or psychiatric clinic for relief from depression. Because the first antidepressant is often ineffective for most patients, a sequence of drug treatments targeting various brain neurochemicals was carefully planned. This article will review the complex treatments and the various outcomes, including the frequency of relapse during twelve months of follow-up care.



Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • John J. Boren
    • 1
  • Allan M. Leventhal
    • 2
  • H. Edmund Pigott
    • 3
  1. 1.Chapel HillUSA
  2. 2.Silver SpringUSA
  3. 3.ClarksvilleUSA