Journal of Clinical Monitoring and Computing

, Volume 27, Issue 5, pp 499–508

Factors affecting hemoglobin measurement


    • Department of Anesthesiology and Critical Care MedicineJohns Hopkins School of Medicine
Review Paper

DOI: 10.1007/s10877-013-9456-3

Cite this article as:
Berkow, L. J Clin Monit Comput (2013) 27: 499. doi:10.1007/s10877-013-9456-3


A review of the literature shows that current “standard” laboratory measurements for hemoglobin are subject to numerous factors that affect both accuracy and reliability. In addition, total hemoglobin concentration measurements are subject to numerous factors that affect the “true” hemoglobin value. This article discusses both the physiologic factors that influence hemoglobin levels and the technical aspects and variability among the different measurement methodologies currently available.


Hemoglobin concentration CO-Oximetry Hematology analyzer Point-of-care Noninvasive

Copyright information

© Springer Science+Business Media New York 2013