, Volume 34, Issue 1, pp 3-6
Date: 24 Jul 2013

Measurement of Pneumococcal Polysaccharide Vaccine Responses for Immunodeficiency Diagnostics: Combined IgG Responses Compared to Serotype Specific IgG Responses

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Introduction

Common variable immunodeficiency (CVID) is a heterogeneous primary immunodeficiency mainly characterized by defective antibody production and markedly reduced serum levels of IgG, IgA and frequently IgM [1]. One hallmark in the diagnosis is a poor response to vaccination [2], which is often gauged by measuring IgG responses to 23-valent pneumococcal polysaccharide (PnPS) vaccine. The majority of childhood vaccination programs now include vaccination against Pneumococcal disease using a 7-, 10- or 13- valent conjugated Pneumococcal vaccine, that has been shown to provide protection against invasive Pneumococcal disease by the serotypes in these vaccines [3]. However, vaccination using a conjugate Pneumococcal (Pn-C) vaccine may interfere with the diagnostic use of the 23-valent polysaccharide vaccine [4].

Different methods for the quantification of the Pn-PS vaccination response are available and in use by diagnostic laboratories, such as IgG measurement of separate serotypes

Funding

This study was supported by a non-restricted educational grant from Baxter The Netherlands