Diabetes, Renal and Cardiovascular Disease in p47phox−/− Chronic Granulomatous Disease
- First Online:
- Cite this article as:
- Leiding, J.W., Marciano, B.E., Zerbe, C.S. et al. J Clin Immunol (2013) 33: 725. doi:10.1007/s10875-013-9871-8
- 277 Views
Chronic granulomatous disease is a rare immunodeficiency due to defects in the phagocyte NADPH oxidase. The X-linked form (gp91phox deficiency) accounts for about 70 % of cases; autosomal recessive p47phox deficiency accounts for about 25 % of cases. We identified a 10 % incidence of diabetes in p47phox deficient CGD, but none in X-linked CGD. Renal and cardiovascular diseases were also higher in p47phox deficiency. p47phox deficient CGD has non-infectious morbidities distinct from those in X-linked CGD.