, Volume 33, Issue 4, pp 725-730

Diabetes, Renal and Cardiovascular Disease in p47 phox−/− Chronic Granulomatous Disease

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Abstract

Chronic granulomatous disease is a rare immunodeficiency due to defects in the phagocyte NADPH oxidase. The X-linked form (gp91 phox deficiency) accounts for about 70 % of cases; autosomal recessive p47 phox deficiency accounts for about 25 % of cases. We identified a 10 % incidence of diabetes in p47 phox deficient CGD, but none in X-linked CGD. Renal and cardiovascular diseases were also higher in p47 phox deficiency. p47 phox deficient CGD has non-infectious morbidities distinct from those in X-linked CGD.

This work supported by the Division of Intramural Research, NIAID, NIH.