, Volume 33, Issue 2, pp 311-312
Date: 25 Oct 2012

Anti-Annexin V Antibodies in Primary Fibromyalgia Syndrome: Relation to Associated Sjögren’s Syndrome

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Fibromyalgia syndrome (FMS) is a complex disorder that affects up to 5 % of the general population worldwide, more frequently in women. Sjögren’s syndrome (SS), the second most common autoimmune rheumatic disease results from immune lymphocytes that infiltrate the lacrimal and salivary glands. The distinction between FMS patients and primary SS remains difficult. Damages to the lacrimal and salivary glands and development of SS may accompany various autoimmune diseases. Apoptosis (programmed cell death) plays a fundamental role in the pathogenesis of SS. Annexins are a group of highly conserved proteins which exert several regulatory functions on cell biology and are involved in numerous cell processes including apoptosis. The aim of this study was to measure the level of serum Anti-Annexin V antibodies in FMS patients diagnosed according to the American College of Rheumatology criteria [1] and to study their significance in relation to associated SS diagnosed according to the revised ...