Journal of Clinical Immunology

, Volume 32, Issue 3, pp 523–529

Effects of High-Dose Dexamethasone on Regulating Interleukin-22 Production and Correcting Th1 and Th22 Polarization in Immune Thrombocytopenia

  • Jiang Cao
  • Chong Chen
  • Li Li
  • Ling-yu Zeng
  • Zhen-yu Li
  • Zhi-ling Yan
  • Wei Chen
  • Hai Cheng
  • Wei Sang
  • Kai-lin Xu
Article

DOI: 10.1007/s10875-012-9649-4

Cite this article as:
Cao, J., Chen, C., Li, L. et al. J Clin Immunol (2012) 32: 523. doi:10.1007/s10875-012-9649-4

Abstract

Background

T-cell dysregulation and T-cell-related cytokine abnormalities are involved in the pathogenesis of immune thrombocytopenia (ITP). One of our previous studies showed that elevated IL-22 correlated to Th1 and Th22 cells plays an important role in the immunopathogenesis of ITP. In this study, we aimed to investigate the effects of high-dose dexamethasone (HD-DXM) on IL-22 production and on the IL-22-producing T-cell subsets in ITP patients.

Methods

IL-22 plasma levels and the percentages of Th1, Th17, and Th22 cells were determined by enzyme-linked immunosorbent assay and flow cytometry in 25 ITP patients receiving DXM 40 mg/day for 4 consecutive days.

Results

Plasma IL-22 concentrations and the percentages of Th1 and Th22 cells were significantly increased in pre-therapy patients relative to controls (P < 0.05), but the percentage of Th17 cells was not. HD-DXM administration reduced IL-22 production and corrected the imbalance between Th1 and Th22 subsets. IL-22 levels were positively correlated with Th1 and Th22 cells in ITP patients before and after HD-DXM treatment.

Conclusion

These results suggest that HD-DXM may regulate the production of IL-22 in ITP, possibly by correcting Th1 and Th22 polarization.

Keywords

High-dose dexamethasone immune thrombocytopenia interleukin-22 Th22 cells 

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Jiang Cao
    • 1
  • Chong Chen
    • 1
  • Li Li
    • 2
  • Ling-yu Zeng
    • 1
  • Zhen-yu Li
    • 1
  • Zhi-ling Yan
    • 1
  • Wei Chen
    • 1
  • Hai Cheng
    • 1
  • Wei Sang
    • 1
  • Kai-lin Xu
    • 1
    • 3
  1. 1.Department of HematologyThe Affiliated Hospital of Xuzhou Medical CollegeXuzhouChina
  2. 2.Department of GastroenterologyThe Affiliated Hospital of Xuzhou Medical CollegeXuzhouChina
  3. 3.Laboratory of Transplantation and ImmunologyXuzhou Medical CollegeXuzhouChina

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