Journal of Clinical Immunology

, Volume 32, Issue 3, pp 604–610

Influence of Maternal Hyperglycemia on IL-10 and TNF-α Production: The Relationship with Perinatal Outcomes

  • Jusciele Brogin Moreli
  • Glilciane Morceli
  • Ana Karina C. De Luca
  • Claudia G. Magalhães
  • Roberto A. A. Costa
  • Débora Cristina Damasceno
  • Marilza Vieira Cunha Rudge
  • Iracema Mattos Paranhos Calderon
Article

DOI: 10.1007/s10875-011-9634-3

Cite this article as:
Moreli, J.B., Morceli, G., De Luca, A.K.C. et al. J Clin Immunol (2012) 32: 604. doi:10.1007/s10875-011-9634-3

Abstract

Aims

This study was conducted to evaluate maternal and placental concentrations of interleukin 10 (IL-10) and tumor necrosis factor-alpha (TNF-α) in pregnant women with glycemic mean (GM) < or ≥100 mg/dL, as well as correlate IL-10 and TNF-α placental concentrations with perinatal outcomes.

Methods

One hundred eighty-six pregnant women were distributed in groups determined by a GM <100 mg/dL or a GM ≥100 mg/dL. The GM, HbA1c levels, maternal and placental concentrations of IL-10 and TNF-α, and the correlation of placental cytokines with perinatal outcomes were evaluated.

Results

In maternal blood, the lowest concentrations of IL-10 (p = 0.0019) and TNF-α (p = 0.0185) were observed in the GM ≥100-mg/dL group. The placentas from GM ≥100 mg/dL group exhibited higher TNF-α concentrations (p = 0.0385). Placental IL-10 directly correlated with hemoglobin (r = 0.63; p = 0.02) and insulin (r = 0.78; p = 0.01) levels in the umbilical cord and with 1-min (r = 0.53; p = 0.0095) and 5-min (r = 0.69; p = 0.0003) Apgar scores. Placental TNF-α displayed a tendency to inversely correlate with fetal weight (r = −0.41; p = 0.05).

Conclusion

Compared to GM <100 mg/dL, GM ≥100 mg/dL was associated with a reduction in maternal IL-10 and TNF-α concentrations and increased placental TNF-α production. Placental IL-10 production was similar in both groups studied and directly correlated with hemoglobin and umbilical cord insulin levels, as well as with the 1- and 5-min Apgar scores.

Keywords

Cytokinesdiabetesmild gestational hyperglycemiaplacentaperinatal outcomes

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Jusciele Brogin Moreli
    • 1
  • Glilciane Morceli
    • 1
  • Ana Karina C. De Luca
    • 2
  • Claudia G. Magalhães
    • 2
  • Roberto A. A. Costa
    • 2
  • Débora Cristina Damasceno
    • 1
    • 2
  • Marilza Vieira Cunha Rudge
    • 1
    • 2
  • Iracema Mattos Paranhos Calderon
    • 1
    • 2
  1. 1.Post-graduate Program in Gynecology, Obstetrics and Mastology, Botucatu Medical SchoolUNESP—São Paulo State UniversityBotucatuBrazil
  2. 2.Department of Obstetrics and Gynecology, Botucatu Medical SchoolUNESP—São Paulo State UniversityBotucatuBrazil