Active Immunological Profile Is Associated with Systemic Sjögren’s Syndrome
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The aim of this paper was to study the evolution of primary Sjögren’s syndrome (pSS) immunological profile, its impact on pSS activity and long-term evolution in a bicentric cohort of French patients with pSS (n = 445, mean age 53.6 ± 14 years, mean follow-up 76.1 ± 51 months).
This is a retrospective cohort study.
Two hundred twelve patients were Sjögren’s syndrome A (SSA) positive, and 131 were both SSA and Sjögren’s syndrome B (SSB) positive. Sixty-eight patients (15%) had cryoglobulinemia. Active systemic profile (i.e., hypergammaglobulinemia, rheumatoid factor (RF), and anti-Sjögren’s syndrome A (anti-SSA), anti-Sjögren’s syndrome B (anti-SSB) positivity), associated with multisystemic involvement, leads to an increased utilization of corticosteroid and hydroxychloroquine. Multivariate analysis pointed out independent statistical association between hypergammaglobulinemia, anti-SSA, anti-SSB, and RF. Cryoglobulinemia is associated with multi-systemic involvement, lymphoma, and pSS-related death.
The subset of patients with active immunological profile is characterized by systemic complications leading to immunosuppressive drug utilization and polyclonal B-cell activation profile.
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- Active Immunological Profile Is Associated with Systemic Sjögren’s Syndrome
Journal of Clinical Immunology
Volume 31, Issue 5 , pp 840-847
- Cover Date
- Print ISSN
- Online ISSN
- Springer US
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- Primary Sjögren syndrome
- anti-SSA antibodies
- rheumatoid factor
- Industry Sectors
- Author Affiliations
- 1. Department of Internal Medicine, Limoges University Hospital, Limoges, France
- 2. Department of Immunology-EA3842, Limoges University Hospital, Limoges, France
- 3. Department of Internal Medicine, Lille University Hospital, Lille, France
- 4. Department of Internal Medicine and EA3842-Immunology, Limoges University Hospital, 87042, Limoges, France