Journal of Clinical Immunology

, Volume 31, Issue 4, pp 584–587

Xenotropic Murine Leukemia Virus-Related Virus (XMRV) in Patients with Systemic Lupus Erythematosus

  • Eva Balada
  • Jesús Castro-Marrero
  • Lledó Felip
  • Miquel Vilardell-Tarrés
  • Josep Ordi-Ros
Article

DOI: 10.1007/s10875-011-9535-5

Cite this article as:
Balada, E., Castro-Marrero, J., Felip, L. et al. J Clin Immunol (2011) 31: 584. doi:10.1007/s10875-011-9535-5

Abstract

Objectives

Xenotropic murine leukemia virus-related virus (XMRV)-specific proviral DNA has been recently detected in peripheral blood mononuclear cells of patients with chronic fatigue syndrome. Since chronic fatigue is commonly reported in patients with systemic lupus erythematosus (SLE) we aimed at testing the presence of this virus in these patients.

Methods

Ninety-five SLE patients, 45 of whom had a Fatigue Severity Scale score higher than 3, were included. Molecular analyses were performed by PCR from DNA obtained from the whole blood of both SLE patients and 50 healthy controls.

Results

None of the 145 samples analyzed yielded the specific XMRV PCR product.

Conclusions

We conclude that XMRV is not detected in blood neither from SLE patients nor from healthy controls. It leads to infer that other environmental and biological triggers (different from XMRV) may account for the increased levels of fatigue over the course of SLE.

Keywords

Systemic lupus erythematosus XMRV chronic fatigue 

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Eva Balada
    • 1
    • 2
  • Jesús Castro-Marrero
    • 1
  • Lledó Felip
    • 1
  • Miquel Vilardell-Tarrés
    • 1
  • Josep Ordi-Ros
    • 1
  1. 1.Research Unit in Systemic Autoimmune Diseases, Vall d’Hebron Research InstituteVall d’Hebron Hospital, Autonomous University of BarcelonaBarcelonaSpain
  2. 2.Research Unit in Systemic Autoimmune Diseases, Vall d’Hebron Research InstituteVall d’Hebron HospitalBarcelonaSpain