Journal of Clinical Immunology

, Volume 31, Issue 2, pp 240–244

CTLA-4, Position 49 A/G Polymorphism Associated with Coronary Artery Lesions in Kawasaki Disease

  • Ho-Chang Kuo
  • Chi-Di Liang
  • Hong-Ren Yu
  • Chih-Lu Wang
  • I-Chun Lin
  • Chieh-An Liu
  • Jen-Chieh Chang
  • Chiu-Ping Lee
  • Wei-Chiao Chang
  • Kuender D. Yang
Article

DOI: 10.1007/s10875-010-9484-4

Cite this article as:
Kuo, HC., Liang, CD., Yu, HR. et al. J Clin Immunol (2011) 31: 240. doi:10.1007/s10875-010-9484-4

Abstract

Objective

Kawasaki disease (KD) is a systemic vasculitis of unknown etiology and primarily affects children less than 5 years of age. Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) has been suggested as a candidate gene for conferring susceptibility to autoimmunity. This study examined the correlation of CTLA-4 gene polymorphisms in KD with and without coronary artery lesions (CAL).

Materials and methods

A total of 233 KD patients and 644 controls were subjected to determination of CTLA-4 polymorphisms at (−318) C/T and (+49) A/G positions by restriction fragment length polymorphism. Susceptibility, CAL, and intravenous immunoglobulin treatment response of KD were then analyzed with genetic variants.

Results

Polymorphisms of CTLA-4 (+49 A/G) and (−318 C/T) were not significantly different between normal children and patients with KD. The CTLA-4 (+49) A allele (AA+AG genotype), however, was significantly associated with CAL formation, especially in female patients.

Conclusions

This study provides the first evidence supporting the association of CTLA-4 (+49) A/G polymorphism with the CAL formation of KD particularly in female patients.

Keywords

Kawasaki diseasecoronary artery lesionsCTLA-4

Abbreviations

KD

Kawasaki disease

IVIG

Intravenous immunoglobulin

CAL

Coronary artery lesions

CTLA-4

Cytotoxic T lymphocyte antigen-4

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Ho-Chang Kuo
    • 1
    • 2
  • Chi-Di Liang
    • 3
  • Hong-Ren Yu
    • 1
    • 2
  • Chih-Lu Wang
    • 4
  • I-Chun Lin
    • 2
  • Chieh-An Liu
    • 1
  • Jen-Chieh Chang
    • 5
    • 6
  • Chiu-Ping Lee
    • 5
  • Wei-Chiao Chang
    • 7
    • 9
  • Kuender D. Yang
    • 1
    • 2
    • 8
  1. 1.Division of Allergy, Immunology and Rheumatology, Department of PediatricsChang Gung Memorial Hospital-Kaohsiung Medical CenterKaohsiungTaiwan
  2. 2.Graduate Institute of Clinical Medical ScienceChang Gung UniversityKaohsiungTaiwan
  3. 3.Division of Cardiology, Department of PediatricsChang Gung Memorial Hospital-Kaohsiung Medical CenterKaohsiungTaiwan
  4. 4.Po-Jen HospitalKaohsiungTaiwan
  5. 5.Clinical Genomic & Proteomic Core Laboratory, Department of Medical ResearchChang Gung Memorial Hospital Kaohsiung Medical CenterKaohsiungTaiwan
  6. 6.Institute of Biomedical SciencesNational Sun Yat-Sen UniversityKaohsiungTaiwan
  7. 7.Department of Medical Genetics, College of MedicineKaohsiung Medical UniversityKaohsiungTaiwan
  8. 8.Department of Medical Research and Pediatric Allergy, Immunology and RheumatologyChang Gung Memorial Hospital-Kaohsiung Medical CenterKaohsiungTaiwan
  9. 9.Cancer CenterKaohsiung Medical University HospitalKaohsiungTaiwan