, Volume 30, Issue 5, pp 632-637
Date: 28 Jul 2010

Inflammasomes and Anti-Viral Immunity

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

Type I Interferons are the hallmark cytokines deployed during infection to combat invading viruses. However, inflammatory cytokines such as Interleukin (IL)-1β and IL-18 also play important roles in anti-viral defenses. The activity of IL-1β and IL18 are regulated at the level of expression, processing, and secretion. Several classes of innate immune receptors control the expression of these cytokines, which must then be proteolytically processed via caspase-1. In this review, we provide an overview of how caspase-1-activating inflammasomes participate during viral infections and their role in regulating anti-viral immunity.