Article

Journal of Clinical Immunology

, Volume 30, Issue 2, pp 185-195

First online:

The IL-17 Family Cytokines in Immunity and Disease

  • Rajita PappuAffiliated withDepartment of Immunology, Genentech, Inc. Email author 
  • , Vladimir Ramirez-CarrozziAffiliated withDepartment of Immunology, Genentech, Inc.
  • , Naruhisa OtaAffiliated withDepartment of Immunology, Genentech, Inc.
  • , Wenjun OuyangAffiliated withDepartment of Immunology, Genentech, Inc.
  • , Yan HuAffiliated withDepartment of Immunology, Genentech, Inc.

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Abstract

Introduction

Accumulating evidence suggests that the interleukin (IL)-17 cytokines are major players in the immune response to foreign pathogens. In addition, the pathogeneses of a number of inflammatory diseases have been linked to uncontrolled expression of these cytokine pathways.

Discussion

Genetic and biochemical analyses have elucidated the cellular and molecular events triggered by these proteins during an inflammatory response. While significant efforts have been placed on understanding the functions of IL-17A, IL-17F, and IL-17E, the significance of the other family members, IL-17B−D, in inflammation remains to be determined.

Conclusion

This review will focus on the cellular sources, target cell/receptors that are utilized by these cytokines to control pathogenesis, and the therapeutic potential of targeting these pathways to treat inflammatory disorders.

Keywords

IL-17 IL-17 receptors cytokines host defense autoimmunity inflammation