IL-17 Contributes to the Development of Chronic Rejection in a Murine Heart Transplant Model
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- Itoh, S., Nakae, S., Axtell, R.C. et al. J Clin Immunol (2010) 30: 235. doi:10.1007/s10875-009-9366-9
Although interleukin-17 (IL-17) has been reported to participate in the pathogenesis of infectious, autoimmune and allergic disorders, the precise role in allograft rejection remains uncertain. This study illustrates that IL-17 contributes to the pathogenesis of chronic allograft rejection.
Utilizing a murine heterotopic heart transplant model system, IL-17-deficient recipient mice had decreased allograft inflammatory cell recruitment, decreased IL-6, MCP-1, and KC production, and reduced graft coronary artery disease (GCAD). Intragraft gamma delta (γδ) T cells appear to be the predominant source of IL-17 production.
Therefore, IL-17 neutralization may provide a potential target for novel therapeutic treatment for cardiac allograft rejection.