IL-17 Contributes to the Development of Chronic Rejection in a Murine Heart Transplant Model
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Although interleukin-17 (IL-17) has been reported to participate in the pathogenesis of infectious, autoimmune and allergic disorders, the precise role in allograft rejection remains uncertain. This study illustrates that IL-17 contributes to the pathogenesis of chronic allograft rejection.
Utilizing a murine heterotopic heart transplant model system, IL-17-deficient recipient mice had decreased allograft inflammatory cell recruitment, decreased IL-6, MCP-1, and KC production, and reduced graft coronary artery disease (GCAD). Intragraft gamma delta (γδ) T cells appear to be the predominant source of IL-17 production.
Therefore, IL-17 neutralization may provide a potential target for novel therapeutic treatment for cardiac allograft rejection.
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- IL-17 Contributes to the Development of Chronic Rejection in a Murine Heart Transplant Model
Journal of Clinical Immunology
Volume 30, Issue 2 , pp 235-240
- Cover Date
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- Springer US
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- graft coronary artery disease
- γδ T cell
- Industry Sectors
- Author Affiliations
- 1. Department of Cardiothoracic Surgery, Stanford University School of Medicine, 300 Pasteur Dr., CVRB MC 5407, Stanford, CA, 94305, USA
- 7. Department of Cardiovascular Surgery, Saitama Medical Center, Jichi Medical University, Saitama, 330-0834, Japan
- 2. Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, 157-8535, Japan
- 3. Atopy Research Center, Juntendo University, Tokyo, 113-8421, Japan
- 4. Frontier Research Initiative, The Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan
- 5. Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA
- 6. Center for Experimental Medicine, The Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan