Journal of Clinical Immunology

, Volume 30, Issue 1, pp 90–98

Chemokine Expression Patterns in the Systemic and Genital Tract Compartments are Associated with HIV-1 Infection in Women from Benin

Authors

  • Julie Lajoie
    • Laboratoire d’immunogénétiqueCentre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM)
    • Département de Microbiologie et ImmunologieHôpital Notre-Dame du Centre Hospitalier de l’Université de Montréal (CHUM)
  • Johanne Poudrier
    • Laboratoire d’immunogénétiqueCentre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM)
    • Département de Microbiologie et ImmunologieHôpital Notre-Dame du Centre Hospitalier de l’Université de Montréal (CHUM)
  • Marguerite Massinga Loembe
    • Laboratory of ImmunologyInstitute of Tropical Medicine
    • Unité de Recherche en Santé des PopulationsCentre hospitalier affilié universitaire de Québec and Université Laval
  • Fernand Guédou
    • Unité de Recherche en Santé des PopulationsCentre hospitalier affilié universitaire de Québec and Université Laval
  • François Leblond
    • Département de Microbiologie de l’hôpital Maisonneuve-Rosemont
  • Annie-Claude Labbé
    • Département de Microbiologie de l’hôpital Maisonneuve-Rosemont
  • Michel Alary
    • Unité de Recherche en Santé des PopulationsCentre hospitalier affilié universitaire de Québec and Université Laval
    • Laboratoire d’immunogénétiqueCentre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM)
    • Département de Microbiologie et ImmunologieHôpital Notre-Dame du Centre Hospitalier de l’Université de Montréal (CHUM)
Article

DOI: 10.1007/s10875-009-9343-3

Cite this article as:
Lajoie, J., Poudrier, J., Massinga Loembe, M. et al. J Clin Immunol (2010) 30: 90. doi:10.1007/s10875-009-9343-3

Abstract

Introduction

Understanding the genital mucosal immunity and the factors involved in linking innate to adaptive immunity is crucial for the design of efficient preventive strategies against human immunodeficiency virus (HIV)-1.

Methods

Levels of both genital mucosal and blood chemokines were compared between 58 HIV-1-uninfected and 50 HIV-1-infected female commercial sex workers (CSWs) as well as 53 HIV-1-uninfected non-CSW control women at low risk for exposure, recruited in Cotonou, Benin.

Results

HIV-1-infected CSWs had significantly higher blood and genital levels of monocyte chemotactic protein (MCP-3/CCL7) and monokine induced by gamma interferon (MIG/CXCL9) compared with those in both the HIV-1-uninfected CSW and non-CSW groups. In the HIV-1-infected group, levels of MCP-3 and MIG were significantly higher in the genital mucosa than in the blood. However, the blood levels of macrophage inflammatory protein (MIP-1a/CCL3) and MIP-1b/CCL4 were higher in HIV-1-uninfected CSWs compared with those in the other groups.

Conclusion

Increased production of chemokines in the genital tract may favour the recruitment of HIV-1 target cells causing a mucosal environment that promotes viral replication and dissemination, whereas higher expression of β-chemokines at the systemic level is associated with protection from HIV-1 infection.

Keywords

Africachemokinefemale genital tractHIVimmunity mucosal and systemic

Copyright information

© Springer Science+Business Media, LLC 2009