Journal of Clinical Immunology

, Volume 29, Issue 2, pp 151–157

Human Immune Memory to Yellow Fever and Smallpox Vaccination

  • Jens Wrammert
  • Joe Miller
  • Rama Akondy
  • Rafi Ahmed
Article

DOI: 10.1007/s10875-008-9267-3

Cite this article as:
Wrammert, J., Miller, J., Akondy, R. et al. J Clin Immunol (2009) 29: 151. doi:10.1007/s10875-008-9267-3

Abstract

Background

Establishment of immunological memory is a hallmark of adaptive immune responses and the biological mechanism for the success of vaccines. However, in humans, much of our knowledge about adaptive immune responses derives from studies of chronic viral infections.

Objective

Here, we summarize the work of our laboratory and others on B and T cell responses and the establishment and maintenance of immune memory after acute viral infections induced by vaccination with two of the most successful vaccines to date, the yellow fever and the smallpox vaccines.

Keywords

B cellsT cellsvaccineimmunological memoryhuman

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Jens Wrammert
    • 1
  • Joe Miller
    • 1
  • Rama Akondy
    • 1
  • Rafi Ahmed
    • 1
  1. 1.Emory Vaccine CenterEmory UniversityAtlantaUSA