Article

Journal of Clinical Immunology

, Volume 28, Issue 6, pp 707-715

Role of Endogenous and Induced Regulatory T Cells During Infections

  • Elizabeth WohlfertAffiliated withMucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
  • , Yasmine BelkaidAffiliated withMucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health Email author 

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Abstract

Background

Various populations of regulatory cells, including Foxp3+ TReg, have been shown to play a central role in the maintenance of peripheral homeostasis and establishment of controlled immune responses.

Objective

In this review, we discuss current hypotheses and points of polemic associated with the origin, mode of action, and antigen specificity of both endogenous and induced regulatory T cells during infections.

Keywords

Regulatory T cells peripheral homeostasis controlled immune response