, Volume 28, Issue 6, pp 707-715
Date: 23 Sep 2008

Role of Endogenous and Induced Regulatory T Cells During Infections

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Abstract

Background

Various populations of regulatory cells, including Foxp3+ TReg, have been shown to play a central role in the maintenance of peripheral homeostasis and establishment of controlled immune responses.

Objective

In this review, we discuss current hypotheses and points of polemic associated with the origin, mode of action, and antigen specificity of both endogenous and induced regulatory T cells during infections.