Journal of Clinical Immunology

, Volume 28, Issue 5, pp 593–599

Expression of Cytokine mRNA in Lymphocytes of Malnourished Children

  • Haydeé González-Martínez
  • Leonor Rodríguez
  • Oralia Nájera
  • David Cruz
  • Angel Miliar
  • Aarón Domínguez
  • Fausto Sánchez
  • Jaime Graniel
  • María Cristina González-Torres
Article

DOI: 10.1007/s10875-008-9204-5

Cite this article as:
González-Martínez, H., Rodríguez, L., Nájera, O. et al. J Clin Immunol (2008) 28: 593. doi:10.1007/s10875-008-9204-5

Abstract

Introduction

Protein–calorie malnutrition represents a significant worldwide health problem and is associated with an increased risk for infections. The purpose of this study was to evaluate possible changes in type 1/type 2 responses balance in malnourished children.

Results

The data obtained in the present study showed that the expression levels of tumor necrosis factor-α, interleukin (IL)-4, and IL-10 were more highly, in contrast IL-2, gamma interferon, and IL-6 genes were expressed less in all groups of malnourished children compared with the well-nourished infected children. It is important to indicate that the data collected in the present work agree with the results obtained by different authors, who showed differences in the production of cytokines in malnourished children.

Conclusion

In conclusion, the results suggest that alterations in the balance of type 1/type 2 immune responses exist in malnourished children, and this could be the reason that the immunological system of the malnourished children is incapable of eradicating infections.

Keywords

Protein–calorie malnutrition immunological responses type 1/type 2 lymphocytes cytokines 

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Haydeé González-Martínez
    • 1
  • Leonor Rodríguez
    • 1
  • Oralia Nájera
    • 2
  • David Cruz
    • 3
  • Angel Miliar
    • 4
  • Aarón Domínguez
    • 5
  • Fausto Sánchez
    • 5
  • Jaime Graniel
    • 6
  • María Cristina González-Torres
    • 1
  1. 1.Departamento de Ciencias de la Salud, División de Ciencias Biológicas y de la SaludUniversidad Autónoma Metropolitana-IztapalapaMéxicoMéxico
  2. 2.Departamento de Atención a la Salud, División de Ciencias Biológicas y de la SaludUniversidad Autónoma Metropolitana-XochimilcoMéxicoMéxico
  3. 3.Departamento de PatologíaInstituto Nacional de Cardiología “Ignacio Chávez”MéxicoMéxico
  4. 4.Sección de Estudios de Posgrado e Investigación, Escuela Superior de MedicinaInstituto Politécnico NacionalMéxicoMéxico
  5. 5.Departamento de GastroenterologíaInstituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMéxicoMéxico
  6. 6.Hospital Pediátrico IztapalapaServicios de Salud Gobierno del Distrito FederalMéxicoMéxico

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