Neutrophil Activation in Patients with ASA-Induced Urticaria
First Online: 17 January 2008 Received: 19 November 2007 Accepted: 14 December 2007 DOI:
10.1007/s10875-007-9165-0 Cite this article as: Choi, S., Ye, Y., Hur, G. et al. J Clin Immunol (2008) 28: 244. doi:10.1007/s10875-007-9165-0 Abstract
The pathogenic mechanism of acetyl salicylic acid (ASA)-induced urticaria (AIU) is not fully understood. We compared the levels of neutrophil activation and related cytokines in patients with ASA-intolerant acute urticaria (AIAU) and ASA-intolerant chronic urticaria (AICU). A total of 51 patients with AIAU, 88 patients with AICU, and 102 normal controls (NC) were enrolled in this study. The serum levels of myeloperoxidase (MPO), interleukin-8 (IL-8), and IL-18 were compared among the three groups. The serum levels of MPO were highest in the AIAU group, followed by the AICU and NC groups, and the serum levels of IL-18 were significantly higher in the AIAU and AICU groups than in NC group. Within the AIU groups, significant correlations were noted between the levels of MPO and IL-8, and IL-8 and IL-18. In conclusion, neutrophil activation, which was associated with the levels of IL-8 and IL-18 in the AIAU group, may be involved in the pathogenic mechanism of AIU. A role for IL-18 in the pathogenesis of AIU is also suggested.
Keywords ASA-intolerant acute urticaria IL-8 IL-18 neutrophil activation References
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