Journal of Clinical Immunology

, Volume 28, Issue 3, pp 244–249

Neutrophil Activation in Patients with ASA-Induced Urticaria

  • Sung-Jin Choi
  • Young-Min Ye
  • Gyu-Young Hur
  • Seung-Youp Shin
  • Jae-Ho Han
  • Hae-Sim Park
Article

DOI: 10.1007/s10875-007-9165-0

Cite this article as:
Choi, S., Ye, Y., Hur, G. et al. J Clin Immunol (2008) 28: 244. doi:10.1007/s10875-007-9165-0

Abstract

The pathogenic mechanism of acetyl salicylic acid (ASA)-induced urticaria (AIU) is not fully understood. We compared the levels of neutrophil activation and related cytokines in patients with ASA-intolerant acute urticaria (AIAU) and ASA-intolerant chronic urticaria (AICU). A total of 51 patients with AIAU, 88 patients with AICU, and 102 normal controls (NC) were enrolled in this study. The serum levels of myeloperoxidase (MPO), interleukin-8 (IL-8), and IL-18 were compared among the three groups. The serum levels of MPO were highest in the AIAU group, followed by the AICU and NC groups, and the serum levels of IL-18 were significantly higher in the AIAU and AICU groups than in NC group. Within the AIU groups, significant correlations were noted between the levels of MPO and IL-8, and IL-8 and IL-18. In conclusion, neutrophil activation, which was associated with the levels of IL-8 and IL-18 in the AIAU group, may be involved in the pathogenic mechanism of AIU. A role for IL-18 in the pathogenesis of AIU is also suggested.

Keywords

ASA-intolerant acute urticariaIL-8IL-18neutrophil activation

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Sung-Jin Choi
    • 1
  • Young-Min Ye
    • 1
  • Gyu-Young Hur
    • 1
  • Seung-Youp Shin
    • 2
  • Jae-Ho Han
    • 3
  • Hae-Sim Park
    • 1
  1. 1.Department of Allergy and RheumatologyAjou University School of MedicineSuwonKorea
  2. 2.Department of OtolaryngologyKyunghee University School of MedicineSeoulKorea
  3. 3.Department of PathologyAjou University School of MedicineSuwonKorea