Journal of Clinical Immunology

, Volume 28, Issue 1, pp 44–49

The Influence of Polymorphisms of Interleukin-17A and Interleukin-17F Genes on the Susceptibility to Ulcerative Colitis

  • Tomiyasu Arisawa
  • Tomomitsu Tahara
  • Tomoyuki Shibata
  • Mitsuo Nagasaka
  • Masakatsu Nakamura
  • Yoshio Kamiya
  • Hiroshi Fujita
  • Masahiko Nakamura
  • Daisuke Yoshioka
  • Yuko Arima
  • Masaaki Okubo
  • Ichiro Hirata
  • Hiroshi Nakano
Article

DOI: 10.1007/s10875-007-9125-8

Cite this article as:
Arisawa, T., Tahara, T., Shibata, T. et al. J Clin Immunol (2008) 28: 44. doi:10.1007/s10875-007-9125-8

Abstract

We investigated the association between ulcerative colitis (UC) and polymorphisms of IL-17A (rs2275913, G-197A) and IL-17F (rs763780, 7488T/C) genes. We employed the multiplex PCR-SSCP method to detect gene polymorphisms. Both the numbers of -197A (IL-17A) and 7488T (IL-17F) alleles were significantly correlated to the development of UC. The frequencies of -197A/A and 7488T/T genotypes in the UC group were significantly higher than those in the non-UC group. An adjusted analysis revealed that -197A and 7488T alleles were independent risk factors for the developing UC. In addition, both polymorphisms were significantly associated with the pancolitis phenotype. Furthermore, -197A allele was significantly correlated to the chronic relapsing phenotype and -197A/A homozygote was more frequent in steroid-dependent cases, whereas 7488T allele was correlated with the chronic continuous phenotype. Our results provided the first evidence that -197A (IL-17A) and 7488T (IL-17F) alleles may influence the susceptibility to and pathophysiological features of UC independently.

Keywords

Interleukin-17 (IL-17) single nucleotide polymorphism (SNP) ulcerative colitis 

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Tomiyasu Arisawa
    • 1
  • Tomomitsu Tahara
    • 1
  • Tomoyuki Shibata
    • 1
  • Mitsuo Nagasaka
    • 1
  • Masakatsu Nakamura
    • 1
  • Yoshio Kamiya
    • 1
  • Hiroshi Fujita
    • 1
  • Masahiko Nakamura
    • 1
  • Daisuke Yoshioka
    • 1
  • Yuko Arima
    • 1
  • Masaaki Okubo
    • 1
  • Ichiro Hirata
    • 1
  • Hiroshi Nakano
    • 1
  1. 1.Department of GastroenterologyFujita Health University School of MedicineToyoakeJapan