Journal of Clinical Immunology

, Volume 27, Issue 4, pp 430–437

Increased Expression of Plasma and CD4+ T Lymphocyte Costimulatory Molecule CD26 in Adult Patients with Allergic Asthma

  • Samantha W. M. Lun
  • C. K. Wong
  • Fanny W. S. Ko
  • David S. C. Hui
  • Christopher W. K. Lam
Article

DOI: 10.1007/s10875-007-9093-z

Cite this article as:
Lun, S.W.M., Wong, C.K., Ko, F.W.S. et al. J Clin Immunol (2007) 27: 430. doi:10.1007/s10875-007-9093-z

CD26, which is a costimulatory molecule and peptidase, is responsible for the degradation of interferon (IFN)-γ-induced chemokines. To elucidate the immunopathological role of CD26 in allergic asthma, we investigated plasma soluble CD26 (sCD26) concentration and its cell surface expression on lymphocytes, monocytes, CD4+ T helper, CD8+ T suppressor plus cytotoxic T, invariant natural killer T (iNKT), and CD19+ B lymphocytes in allergic asthmatic patients. Plasma sCD26 was significantly elevated in asthmatic patients regardless of inhaled corticosteroid treatment (all P < 0.05). Cell surface expression of CD26 was significantly up-regulated on lymphocytes, especially on CD4+ and iNKT lymphocytes (all P < 0.05), but not on other cell types. Significant positive correlations were found between sCD26 and the percentage of eosinophils, Th2-related chemokines CCL5 and CCL22, and costimulatory molecule sCTLA-4 (all P < 0.05). In conclusion, the aberrant expression of CD26 may contribute to the inflammatory process and Th2 predominance in the immunopathogenesis of allergic asthma.

KEY WORDS:

allergy asthma costimulatory molecules CD26 T lymphocytes 

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Samantha W. M. Lun
    • 1
  • C. K. Wong
    • 1
  • Fanny W. S. Ko
    • 2
  • David S. C. Hui
    • 2
  • Christopher W. K. Lam
    • 1
    • 3
  1. 1.Department of Chemical PathologyThe Chinese University of Hong Kong, Prince of Wales HospitalShatinHong Kong
  2. 2.Department of Medicine and TherapeuticsThe Chinese University of Hong Kong, Prince of Wales HospitalShatinHong Kong
  3. 3.Department of Chemical PathologyThe Chinese University of Hong Kong, Prince of Wales HospitalShatinHong Kong