Journal of Clinical Immunology

, Volume 27, Issue 3, pp 233–245

Intravenous Immunoglobulin: An Update on the Clinical Use and Mechanisms of Action

  • VIR-SINGH NEGI
  • SRIRAMULU ELLURU
  • SOPHIE SIBÉRIL
  • STÉPHANIE GRAFF-DUBOIS
  • LUC MOUTHON
  • MICHEL D. KAZATCHKINE
  • SÉBASTIEN LACROIX-DESMAZES
  • JAGADEESH BAYRY
  • SRINI V. KAVERI
Original Paper

DOI: 10.1007/s10875-007-9088-9

Cite this article as:
NEGI, VS., ELLURU, S., SIBÉRIL, S. et al. J Clin Immunol (2007) 27: 233. doi:10.1007/s10875-007-9088-9

Initially used as a replacement therapy for immunodeficiency diseases, intravenous immunoglobulin (IVIg) is now widely used for a number of autoimmune and inflammatory diseases. Considerable progress has been made in understanding the mechanisms by which IVIg exerts immunomodulatory effects in autoimmune and inflammatory disorders. The mechanisms of action of IVIg are complex, involving modulation of expression and function of Fc receptors, interference with activation of complement and the cytokine network and of idiotype network, regulation of cell growth, and effects on the activation, differentiation, and effector functions of dendritic cells, and T and B cells.

KEY WORDS:

Intravenous immunoglobulinsautoimmunityinflammationimmune-modulation

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • VIR-SINGH NEGI
    • 3
  • SRIRAMULU ELLURU
    • 1
    • 2
  • SOPHIE SIBÉRIL
    • 1
  • STÉPHANIE GRAFF-DUBOIS
    • 1
  • LUC MOUTHON
    • 4
  • MICHEL D. KAZATCHKINE
    • 1
  • SÉBASTIEN LACROIX-DESMAZES
    • 1
  • JAGADEESH BAYRY
    • 1
  • SRINI V. KAVERI
    • 1
    • 5
  1. 1.INSERM UMRS 872, Université René Descartes (Paris-5)Université Pierre et Marie Curie (UPMC Paris-6) and Equipe 16-Immuno-pathology and Therapeutic Intervention, Centre de Recherche des CordeliersParisFrance
  2. 2.Université de TechnologieCompiègneFrance
  3. 3.Department of MedicineJawaharlal Institute of Postgraduate Medical Education and ResearchPondicherryIndia
  4. 4.Service de Médecine InterneCentre de Référence pour les vascularites et la sclérodermie systémique, Assistance Publique-Hôpitaux de Paris, Hôpital Cochin, Faculté de Médecine, Université Paris-DescartesParisFrance
  5. 5.INSERM UMRS 872Equipe 16-Immunopathology and Therapeutic Intervention, Centre de Recherche des CordeliersParisFrance