Article

Journal of Clinical Immunology

, Volume 27, Issue 1, pp 19-35

“Spicing Up” of the Immune System by Curcumin

  • Ganesh Chandra JagetiaAffiliated withCytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center
  • , Bharat B. AggarwalAffiliated withCytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer CenterDepartment of Experimental Therapeutics, Unit 143, The University of Texas M. D. Anderson Cancer Center Email author 

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Curcumin (diferuloylmethane) is an orange-yellow component of turmeric (Curcuma longa), a spice often found in curry powder. Traditionally known for its an antiinflammatory effects, curcumin has been shown in the last two decades to be a potent immunomodulatory agent that can modulate the activation of T cells, B cells, macrophages, neutrophils, natural killer cells, and dendritic cells. Curcumin can also downregulate the expression of various proinflammatory cytokines including TNF, IL-1, IL-2, IL-6, IL-8, IL-12, and chemokines, most likely through inactivation of the transcription factor NF-κB. Interestingly, however, curcumin at low doses can also enhance antibody responses. This suggests that curcumin’s reported beneficial effects in arthritis, allergy, asthma, atherosclerosis, heart disease, Alzheimer’s disease, diabetes, and cancer might be due in part to its ability to modulate the immune system. Together, these findings warrant further consideration of curcumin as a therapy for immune disorders.

KEY WORDS

Curcumin tumor necrosis factor nuclear factor-κB interleukins chemokines immunomodulation