Journal of Clinical Immunology

, Volume 27, Issue 2, pp 145–151

High Incidence of Morphological Myelodysplasia and Apoptotic Bone Marrow Cells in Behçet’s Disease

  • Kosei Arimura
  • Naomichi Arima
  • Kakushi Matsushita
  • Masaki Akimoto
  • Chi Young Park
  • Kimiharu Uozumi
  • Chuwa Tei
Article

DOI: 10.1007/s10875-006-9064-9

Cite this article as:
Arimura, K., Arima, N., Matsushita, K. et al. J Clin Immunol (2007) 27: 145. doi:10.1007/s10875-006-9064-9

Behçet’s disease (BD) is a systemic inflammatory disorder of unknown etiology, and rarely complicated with myelodysplastic syndrome (MDS). In the present study, we investigated the morphological myelodysplasia and apoptotic rate of bone marrow cells in 15 patients with BD in comparison with MDS patients. Morphological myelodysplasia of bone marrow cells was detected in 53.3% of BD, but none showed chromosomal abnormalities. The apoptotic rate in BD patients (26.1 ± 8.4%) was significantly higher in normal controls (11.3 ± 2.4%; p < 0.005) and significantly lower in patients with MDS (50.8 ± 14.0%; p < 0.0001). These findings suggest that myelodysplasia in patients with BD is more frequent than expected, and possibly due to excess induction of apoptosis of bone marrow cells in BD. However, the rate of apoptotic bone marrow cells is lower than MDS, which may explain the slight peripheral cytopenia in BD, distinct from that in MDS.

KEY WORDS

Behçet’s disease myelodysplastic syndrome apoptosis morphological myelodysplasia in situ end labeling method bone marrow cells 

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Kosei Arimura
    • 1
    • 4
  • Naomichi Arima
    • 2
  • Kakushi Matsushita
    • 1
  • Masaki Akimoto
    • 1
  • Chi Young Park
    • 1
  • Kimiharu Uozumi
    • 2
  • Chuwa Tei
    • 3
  1. 1.Department of Hematology and ImmunologyKagoshima University HospitalKagoshimaJapan
  2. 2.Division of Host Response, Center for Chronic Viral Diseases, Graduate School of Medical and Dental SciencesKagoshima UniversityKagoshimaJapan
  3. 3.Department of Cardiovascular, Respiratory, and Metabolic Medicine, Graduate School of Medical and Dental SciencesKagoshima UniversityKagoshimaJapan
  4. 4.Department of Hematology and ImmunologyKagoshima University HospitalKagoshimaJapan

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