Journal of Clinical Immunology

, Volume 27, Issue 1, pp 109–116

The Effect of Natural Killer Cell Killer Ig-Like Receptor Alloreactivity on the Outcome of Bone Marrow Stem Cell Transplantation for Severe Combined Immunodeficiency (SCID)

Authors

  • M. D. KELLER
    • Division of Pediatric Allergy and ImmunologyDuke University Medical Center
  • D.-F. CHEN
    • Clinical Transplantation Immunology LaboratoryDuke University Medical Center
  • S. A. CONDRON
    • Duke School of MedicineDuke University Medical Center
  • N. LIU
    • Clinical Transplantation Immunology LaboratoryDuke University Medical Center
  • N. L. REINSMOEN
    • Clinical Transplantation Immunology LaboratoryDuke University Medical Center
    • Division of Pediatric Allergy and ImmunologyDuke University Medical Center
    • Duke University Medical Center
Original Paper

DOI: 10.1007/s10875-006-9058-7

Cite this article as:
KELLER, M.D., CHEN, D., CONDRON, S.A. et al. J Clin Immunol (2007) 27: 109. doi:10.1007/s10875-006-9058-7

Natural killer (NK) cell alloreactions against recipient cells in the setting of bone marrow transplantation have been associated with decreased rates of graft-versus-host disease (GVHD) and improved survival in transplant recipients with myeloid leukemia. These alloreactions are predicted by the absence of recipient HLA class I ligands for donor inhibitory killer Ig-like receptors (KIR). We hypothesized that donor NK cell alloreactions against recipient cells may affect the development of T and B-cell functions and incidence of GVHD in infants with severe combined immunodeficiency (SCID). Of the 156 patients with SCID who had received related bone marrow transplants without pretransplant chemotherapy or posttransplant GVHD prophylaxis, 137 patient–donor pairs were evaluated for the absence of recipient HLA class I ligands for donor inhibitory KIR. Analysis showed that the absence of a KIR ligand had no effect on the incidence or severity of GVHD (R 2 = 0.95, p = 0.84), development of T-cell function (R 2 = 1.05, p = 0.69), production of IgA (p = 0.46) or IgM (p = 0.33), or on 5-year survival (R 2 = 1.21, p = 0.10). Further, in patients possessing native NK cells, the absence of KIR ligands in donors for recipient-inhibitory KIR did not alter transplantation outcomes. This study suggests that inhibitory KIR/HLA interactions do not play a significant role in bone marrow transplantation for SCID.

KEY WORDS

Natural killer cells Immunodeficiency Killer Ig-like receptors Hematopoietic stem cell transplantation

Copyright information

© Springer Science+Business Media, LLC 2006