Journal of Clinical Immunology

, Volume 26, Issue 1, pp 7-11

First online:

Infants Presenting with Recurrent Infections and Low Immunoglobulins: Characteristics and Analysis of Normalization

  • M. A. WhelanAffiliated withDivision of Allergy & Immunology, Thomas Jefferson University
  • , W. H. HwanAffiliated withDivision of Allergy & Immunology, Thomas Jefferson University
  • , J. BeausoleilAffiliated withDivision of Allergy & Immunology, Children's Hospital of Pennsylvania
  • , W. W. HauckAffiliated withBiostatistics Section Division of Pharmacology, Thomas Jefferson University
  • , S. J. McgeadyAffiliated withDivision of Allergy & Immunology, Alfred I. duPont Hospital for Children, Nemours Children's ClinicDivision of Allergy & Immunology, Alfred I. duPont Hospital for Children Email author 

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To better characterize infants presenting with diminished immunoglobulin levels and intact antibody formation, we present 49 such infants, correlating presenting characteristics with history and time to immunoglobulin normalization. Term infants with the following characteristics were included: 1) one or more immunoglobulin classes > 2SD below mean, 2) protective antibody titer to tetanus and diphtheria, 3) intact cellular immunity, 4) no features of other syndromes. The children were 69.4% male and had recurrent otitis media (77.6%), wheezing (61.2%), and atopy (26.5%). Diminished IgA (95.9%) was most common, but 65.3% had multiple isotypes diminished. During follow-up, 25/49 (51%) normalized immunoglobulins, of whom 80% were male; only 48% normalized in infancy. Female immunoglobulin normalization was significantly delayed (p < .001). No deaths or serious infections occurred. This phenotype is predominantly seen in male infants with otitis media and wheezing. Female infants have significantly delayed immunoglobulin normalization. Transient hypogammaglobulinemia of infancy can be diagnosed only retrospectively.


Atopy immunoglobulin normalization low immuno-globulins primary immune deficiency transient hypogammaglobulinemia of infancy (THI)